2IJD

Crystal Structure of the Poliovirus Precursor Protein 3CD

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0003723	molecular_function	RNA binding
1	0003968	molecular_function	RNA-directed RNA polymerase activity
1	0004197	molecular_function	cysteine-type endopeptidase activity
1	0006351	biological_process	DNA-templated transcription
1	0006508	biological_process	proteolysis
1	0039694	biological_process	viral RNA genome replication
2	0003723	molecular_function	RNA binding
2	0003968	molecular_function	RNA-directed RNA polymerase activity
2	0004197	molecular_function	cysteine-type endopeptidase activity
2	0006351	biological_process	DNA-templated transcription
2	0006508	biological_process	proteolysis
2	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN 1 645

Chain	Residue
1	ASP446
1	HIS453
1	HIS455
1	CYS464

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN 2 645

Chain	Residue
2	ASP446
2	HIS453
2	HIS455
2	CYS464

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 1 646

Chain	Residue
1	ARG134
1	GLN65

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 2 646

Chain	Residue
2	GLN65
2	ARG134

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 1 647

Chain	Residue
1	LYS350

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 2 647

Chain	Residue
2	ARG346
2	SER347
2	LYS350
2	SO4648

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 2 648

Chain	Residue
2	LYS350
2	ARG357
2	SO4647

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 1 648

Chain	Residue
1	SER347
1	LYS350
1	LYS542

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 2 649

Chain	Residue
2	ARG598
2	PRO631
2	THR635
2	ARG639

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 1 649

Chain	Residue
1	ARG598
1	PRO631
1	ARG639

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"For protease 3C activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01222","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"description":"For protease 3C activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01222","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8097606","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21148772","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21148772","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2196557","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Site: {"description":"Cleavage; by protease 3C","evidences":[{"source":"UniProtKB","id":"P03301","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1cqq

Chain	Residue	Details
1	GLY145
1	HIS40
1	GLU71
1	ALA147

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1cqq

Chain	Residue	Details
2	GLY145
2	HIS40
2	GLU71
2	ALA147

---