2IE3
Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform | polymer | 589 | 65378.3 | 1 | UniProt (Q96DH3) Pfam (PF02985) UniProt (by SIFTS) (P30153) | Homo sapiens (human) | Protein Phosphatase 2A |
| 2 | B (C) | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 309 | 35650.2 | 1 | UniProt (P67775) Pfam (PF00149) | Homo sapiens (human) | serine/threonine protein phosphatase; PP2A-alpha; Replication protein C; RP-C |
| 3 | C (I) | microcystin LR | polymer | 7 | 1014.2 | 1 | NOR (NOR00109) BIRD (PRD_000212) | Cyanobacteria | |
| 4 | D, E (C) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) |
Sequence modifications
C: 1 - 309 (UniProt: P67775)
| PDB | External Database | Details |
|---|---|---|
| Leu 5 | Val 5 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 102042.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 109.9 | |
| All* | Total formula weight | 102152.6 |
