2IAM
Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 182 | 21155.9 | 1 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA, major histocompatibility complex class II HLA-DR1 alpha chain |
| 2 | B (B) | HLA class II histocompatibility antigen, DRB1-1 beta chain | polymer | 190 | 22080.7 | 1 | UniProt (P04229) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911) | Homo sapiens (human) | MHC class I antigen DRB1*1, DR-1, DR1, major histocompatibility complex class II HLA-DR1 beta chain |
| 3 | C (P) | 15-mer peptide from Triosephosphate isomerase | polymer | 15 | 1481.7 | 1 | UniProt (P60174) | Homo sapiens (human) | |
| 4 | D (C) | CD4+ T cell receptor E8 alpha chain | polymer | 202 | 22399.7 | 1 | UniProt (P01848) Pfam (PF09291) | Homo sapiens (human) | |
| 5 | E (D) | CD4+ T cell receptor E8 beta chain | polymer | 240 | 27088.2 | 1 | UniProt (P01850) Pfam (PF07654) | Homo sapiens (human) | |
| 6 | F, G, H, I, J (A, B, P, C, D) | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
P: 23 - 37 (UniProt: P60174)
| PDB | External Database | Details |
|---|---|---|
| Ile 28 | Thr 27 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94206.2 | |
| All* | Total formula weight | 94206.2 |
