2I9B

Crystal structure of ATF-urokinase receptor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Urokinase-type plasminogen activator	polymer	145	16398.5	4	UniProt (P00749) Pfam (PF00051) In PDB	Homo sapiens (human)
2	E, F, G, H	Urokinase plasminogen activator surface receptor	polymer	279	31110.0	4	UniProt (Q03405) Pfam (PF00021) In PDB	Homo sapiens (human)	uPAR, U- PAR, Monocyte activation antigen Mo3, CD87 antigen
3	I, J	beta-D-mannopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G73474XW)
4	K, L	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	E, F	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6		water	water		18.0	52	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 143 (UniProt: P00749)

PDB	External Database	Details
Arg -1	-	cloning artifact
Ser 0	-	cloning artifact

E, F, G, H: 1 - 277 (UniProt: Q03405)

PDB	External Database	Details
Arg -1	-	cloning artifact
Ser 0	-	cloning artifact
Gln 162	Asn 184	engineered mutation
Gln 172	Asn 194	engineered mutation
Gln 200	Asn 222	engineered mutation
Gln 233	Asn 255	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	190033.7
Branched	Number of molecules	4
	Total formula weight	2021.9
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	192247.7

*Water molecules are not included.