2I6K

Crystal structure of human type I IPP isomerase complexed with a substrate analog

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Isopentenyl-diphosphate delta-isomerase 1	polymer	235	27608.8	2	UniProt (Q13907) Pfam (PF00293) In PDB	Homo sapiens (human)	IPP isomerase 1, Isopentenyl pyrophosphate isomerase 1, IPPI1
2	A, B	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
3	A, B	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	A, B	AMINOETHANOLPYROPHOSPHATE	non-polymer		221.0	2	Chemie (EA2)
5	A, B	ACETIC ACID	non-polymer		60.1	4	Chemie (ACY)
6		water	water		18.0	140	Chemie (HOH)

Sequence modifications

A, B: 1 - 227 (UniProt: Q13907)

PDB	External Database	Details
Mse -7	-	initiating methionine
Gly -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Mse 157	Lys 157	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	55217.6
Non-Polymers*	Number of molecules	12
	Total formula weight	889.4
All*	Total formula weight	56107.0

*Water molecules are not included.