2I60
Crystal structure of [Phe23]M47, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 GP120 envelope glycoprotein and anti-HIV-1 antibody 17B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | G, P | EXTERIOR MEMBRANE GLYCOPROTEIN(GP120) | polymer | 313 | 34838.7 | 2 | UniProt (P35961) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | HIV-1 YU2 GP120 |
| 2 | L, Q | ANTIBODY 17B LIGHT CHAIN | polymer | 214 | 23399.9 | 2 | Homo sapiens (human) | ||
| 3 | H, R | ANTIBODY 17B HEAVY CHAIN | polymer | 229 | 24457.4 | 2 | Homo sapiens (human) | ||
| 4 | M, S | [PHE23]M47, SCORPION-TOXIN MIMIC OF CD4 | polymer | 27 | 2945.6 | 2 | synthetic construct | ||
| 5 | G, P | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 16 | Chemie (NAG) | |||
| 6 | G, P | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 2 | Chemie (IPA) | |||
| 7 | water | water | 18.0 | 485 | Chemie (HOH) |
Sequence modifications
G, P: 83 - 127 (UniProt: P35961)
G, P: 195 - 297 (UniProt: P35961)
G, P: 330 - 492 (UniProt: P35961)
| PDB | External Database | Details |
|---|---|---|
| Gly 79 | - | cloning artifact |
| Ala 80 | - | cloning artifact |
| Arg 81 | - | cloning artifact |
| Ser 82 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Gly 128 | - | linker |
| Ala 129 | - | linker |
| Gly 194 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 298 | - | linker |
| Ala 299 | - | linker |
| Gly 329 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 171283.2 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3659.5 | |
| All* | Total formula weight | 174942.8 |
