2I0Y

cFMS tyrosine kinase (FGF KID) in complex with an arylamide inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	cFMS Tyrosine Kinase	polymer	335	38064.5	1	UniProt (P07333) Pfam (PF07714) In PDB	Homo sapiens (human)
2	A	5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE	non-polymer		339.4	1	Chemie (5CN)
3		water	water		18.0	101	Chemie (HOH)

Sequence modifications

A: 538 - 678 (UniProt: P07333)

PDB	External Database	Details
Gly 535	-	expression tag
Val 536	-	expression tag
Asp 537	-	expression tag

A: 753 - 922 (UniProt: P07333)

PDB	External Database	Details
Arg 679	-	SEE REMARK 999
Pro 680	-	SEE REMARK 999
Pro 681	-	SEE REMARK 999
Gly 682	-	SEE REMARK 999
Leu 683	-	SEE REMARK 999
Glu 684	-	SEE REMARK 999
Tyr 685	-	SEE REMARK 999
Ser 686	-	SEE REMARK 999
Tyr 687	-	SEE REMARK 999
Asn 688	-	SEE REMARK 999
Pro 689	-	SEE REMARK 999
Ser 690	-	SEE REMARK 999
His 691	-	SEE REMARK 999
Asn 692	-	SEE REMARK 999
Pro 693	-	SEE REMARK 999
Glu 694	-	SEE REMARK 999
Glu 695	-	SEE REMARK 999
Gln 696	-	SEE REMARK 999
Leu 697	-	SEE REMARK 999
Ser 698	-	SEE REMARK 999
Ser 699	-	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38064.5
Non-Polymers*	Number of molecules	1
	Total formula weight	339.4
All*	Total formula weight	38403.9

*Water molecules are not included.