2HYI
Structure of the human exon junction complex with a trapped DEAD-box helicase bound to RNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (F, L) | 5'-R(*UP*UP*UP*UP*UP*U)-3' | polymer | 6 | 1792.0 | 2 | |||
| 2 | C, G (A, G) | Protein mago nashi homolog | polymer | 146 | 17189.6 | 2 | UniProt (P61326) Pfam (PF02792) | Homo sapiens (human) | |
| 3 | D, H (B, H) | RNA-binding protein 8A | polymer | 91 | 10370.5 | 2 | UniProt (Q9Y5S9) Pfam (PF00076) | Homo sapiens (human) | RNA-binding motif protein 8A, Ribonucleoprotein RBM8A, RNA-binding protein Y14, Binder of OVCA1- 1, BOV-1 |
| 4 | E, I (C, I) | Probable ATP-dependent RNA helicase DDX48 | polymer | 413 | 47173.2 | 2 | UniProt (P38919) Pfam (PF00270) Pfam (PF00271) | Homo sapiens (human) | DEAD box protein 48, Eukaryotic initiation factor 4A-like NUK-34, Nuclear matrix protein 265, hNMP 265, Eukaryotic translation initiation factor 4A isoform 3 |
| 5 | F, J (D, J) | Protein CASC3 | polymer | 77 | 9435.4 | 2 | UniProt (O15234) Pfam (PF09405) | Homo sapiens (human) | Cancer susceptibility candidate gene 3 protein, Metastatic lymph node protein 51, MLN 51 protein, Barentsz protein, Btz |
| 6 | K, M (C, I) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | L, N (C, I) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 8 | O, P, Q, R, S... (F, L, A, B, C...) | water | water | 18.0 | 660 | Chemie (HOH) |
Sequence modifications
C, I: 1 - 411 (UniProt: P38919)
| PDB | External Database | Details |
|---|---|---|
| Leu 412 | - | cloning artifact |
| Glu 413 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 171921.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1061.0 | |
| All* | Total formula weight | 172982.6 |
