2HW5

The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Enoyl-CoA hydratase	polymer	286	31077.6	6	UniProt (P30084) Pfam (PF00378)	Homo sapiens (human)	Short chain enoyl-CoA hydratase, SCEH, Enoyl-CoA hydratase 1
2	G, I, J, L (A, C, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG) PubChem (888)
3	H, K (B, C)	CROTONYL COENZYME A	non-polymer		835.6	2	Chemie (COO) PubChem (92856) PubChem (44129625) PubChem (644064) PubChem (49858428) PubChem (5462197) PubChem (5497143) PubChem (592) PubChem (87657467) PubChem (11535197) PubChem (5280381) PubChem (125032976) PubChem (125032975) PubChem (135071021) PubChem (137349110) PubChem (124929931) PubChem (124929932) PubChem (129316461) PubChem (136212782) PubChem (171391426) PubChem (163337851)

Sequence modifications

A, B, C, D, E, F: 28 - 290 (UniProt: P30084)

PDB	External Database	Details
Met 5	-	initiating methionine
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
Ser 12	-	cloning artifact
Ser 13	-	cloning artifact
Gly 14	-	cloning artifact
Val 15	-	cloning artifact
Asp 16	-	cloning artifact
Leu 17	-	cloning artifact
Gly 18	-	cloning artifact
Thr 19	-	cloning artifact
Glu 20	-	cloning artifact
Asn 21	-	cloning artifact
Leu 22	-	cloning artifact
Tyr 23	-	cloning artifact
Phe 24	-	cloning artifact
Gln 25	-	cloning artifact
Ser 26	-	cloning artifact
Met 27	-	cloning artifact
Ile 75	Thr 75	variant

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	186465.5
Non-Polymers*	Number of molecules	6
	Total formula weight	1768.4
All*	Total formula weight	188234.0

*Water molecules are not included.