2HW5
The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004165 | molecular_function | delta(3)-delta(2)-enoyl-CoA isomerase activity |
A | 0004300 | molecular_function | enoyl-CoA hydratase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006631 | biological_process | fatty acid metabolic process |
A | 0006635 | biological_process | fatty acid beta-oxidation |
A | 0009083 | biological_process | branched-chain amino acid catabolic process |
A | 0016829 | molecular_function | lyase activity |
A | 0016836 | molecular_function | hydro-lyase activity |
A | 0016853 | molecular_function | isomerase activity |
A | 0043956 | molecular_function | 3-hydroxypropionyl-CoA dehydratase activity |
A | 0120092 | molecular_function | crotonyl-CoA hydratase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004165 | molecular_function | delta(3)-delta(2)-enoyl-CoA isomerase activity |
B | 0004300 | molecular_function | enoyl-CoA hydratase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0006631 | biological_process | fatty acid metabolic process |
B | 0006635 | biological_process | fatty acid beta-oxidation |
B | 0009083 | biological_process | branched-chain amino acid catabolic process |
B | 0016829 | molecular_function | lyase activity |
B | 0016836 | molecular_function | hydro-lyase activity |
B | 0016853 | molecular_function | isomerase activity |
B | 0043956 | molecular_function | 3-hydroxypropionyl-CoA dehydratase activity |
B | 0120092 | molecular_function | crotonyl-CoA hydratase activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0004165 | molecular_function | delta(3)-delta(2)-enoyl-CoA isomerase activity |
C | 0004300 | molecular_function | enoyl-CoA hydratase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005739 | cellular_component | mitochondrion |
C | 0005759 | cellular_component | mitochondrial matrix |
C | 0006631 | biological_process | fatty acid metabolic process |
C | 0006635 | biological_process | fatty acid beta-oxidation |
C | 0009083 | biological_process | branched-chain amino acid catabolic process |
C | 0016829 | molecular_function | lyase activity |
C | 0016836 | molecular_function | hydro-lyase activity |
C | 0016853 | molecular_function | isomerase activity |
C | 0043956 | molecular_function | 3-hydroxypropionyl-CoA dehydratase activity |
C | 0120092 | molecular_function | crotonyl-CoA hydratase activity |
D | 0003824 | molecular_function | catalytic activity |
D | 0004165 | molecular_function | delta(3)-delta(2)-enoyl-CoA isomerase activity |
D | 0004300 | molecular_function | enoyl-CoA hydratase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005739 | cellular_component | mitochondrion |
D | 0005759 | cellular_component | mitochondrial matrix |
D | 0006631 | biological_process | fatty acid metabolic process |
D | 0006635 | biological_process | fatty acid beta-oxidation |
D | 0009083 | biological_process | branched-chain amino acid catabolic process |
D | 0016829 | molecular_function | lyase activity |
D | 0016836 | molecular_function | hydro-lyase activity |
D | 0016853 | molecular_function | isomerase activity |
D | 0043956 | molecular_function | 3-hydroxypropionyl-CoA dehydratase activity |
D | 0120092 | molecular_function | crotonyl-CoA hydratase activity |
E | 0003824 | molecular_function | catalytic activity |
E | 0004165 | molecular_function | delta(3)-delta(2)-enoyl-CoA isomerase activity |
E | 0004300 | molecular_function | enoyl-CoA hydratase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005739 | cellular_component | mitochondrion |
E | 0005759 | cellular_component | mitochondrial matrix |
E | 0006631 | biological_process | fatty acid metabolic process |
E | 0006635 | biological_process | fatty acid beta-oxidation |
E | 0009083 | biological_process | branched-chain amino acid catabolic process |
E | 0016829 | molecular_function | lyase activity |
E | 0016836 | molecular_function | hydro-lyase activity |
E | 0016853 | molecular_function | isomerase activity |
E | 0043956 | molecular_function | 3-hydroxypropionyl-CoA dehydratase activity |
E | 0120092 | molecular_function | crotonyl-CoA hydratase activity |
F | 0003824 | molecular_function | catalytic activity |
F | 0004165 | molecular_function | delta(3)-delta(2)-enoyl-CoA isomerase activity |
F | 0004300 | molecular_function | enoyl-CoA hydratase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005739 | cellular_component | mitochondrion |
F | 0005759 | cellular_component | mitochondrial matrix |
F | 0006631 | biological_process | fatty acid metabolic process |
F | 0006635 | biological_process | fatty acid beta-oxidation |
F | 0009083 | biological_process | branched-chain amino acid catabolic process |
F | 0016829 | molecular_function | lyase activity |
F | 0016836 | molecular_function | hydro-lyase activity |
F | 0016853 | molecular_function | isomerase activity |
F | 0043956 | molecular_function | 3-hydroxypropionyl-CoA dehydratase activity |
F | 0120092 | molecular_function | crotonyl-CoA hydratase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG C 291 |
Chain | Residue |
C | GLU164 |
site_id | AC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG D 291 |
Chain | Residue |
D | GLU164 |
site_id | AC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG C 292 |
Chain | Residue |
C | ALA206 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE COO B 1 |
Chain | Residue |
D | LYS92 |
D | ALA98 |
D | ASP99 |
D | ILE100 |
D | LYS101 |
A | PHE279 |
A | LYS282 |
C | COO2 |
D | LYS56 |
D | ALA57 |
D | ALA60 |
site_id | AC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE COO C 2 |
Chain | Residue |
A | LYS282 |
B | COO1 |
B | PHE279 |
C | LYS56 |
C | ALA57 |
C | ALA60 |
C | LYS92 |
C | ALA98 |
C | ASP99 |
C | ILE100 |
C | LYS101 |
C | TYR137 |
C | PHE139 |
Functional Information from PROSITE/UniProt
site_id | PS00166 |
Number of Residues | 21 |
Details | ENOYL_COA_HYDRATASE Enoyl-CoA hydratase/isomerase signature. IAaVNGyafGGGcelaMmCDI |
Chain | Residue | Details |
A | ILE131-ILE151 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: |
Chain | Residue | Details |
A | ALA98 | |
E | GLY141 | |
F | ALA98 | |
F | GLY141 | |
A | GLY141 | |
B | ALA98 | |
B | GLY141 | |
C | ALA98 | |
C | GLY141 | |
D | ALA98 | |
D | GLY141 | |
E | ALA98 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | SITE: Important for catalytic activity => ECO:0000250 |
Chain | Residue | Details |
A | GLU164 | |
B | GLU164 | |
C | GLU164 | |
D | GLU164 | |
E | GLU164 | |
F | GLU164 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | THR46 | |
B | THR46 | |
C | THR46 | |
D | THR46 | |
E | THR46 | |
F | THR46 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q8BH95 |
Chain | Residue | Details |
A | LYS101 | |
E | LYS115 | |
F | LYS101 | |
F | LYS115 | |
A | LYS115 | |
B | LYS101 | |
B | LYS115 | |
C | LYS101 | |
C | LYS115 | |
D | LYS101 | |
D | LYS115 | |
E | LYS101 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER114 | |
B | SER114 | |
C | SER114 | |
D | SER114 | |
E | SER114 | |
F | SER114 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS118 | |
B | LYS118 | |
C | LYS118 | |
D | LYS118 | |
E | LYS118 | |
F | LYS118 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8BH95 |
Chain | Residue | Details |
A | LYS204 | |
B | LYS204 | |
C | LYS204 | |
D | LYS204 | |
E | LYS204 | |
F | LYS204 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8BH95 |
Chain | Residue | Details |
A | LYS211 | |
B | LYS211 | |
C | LYS211 | |
D | LYS211 | |
E | LYS211 | |
F | LYS211 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
A | ALA98 | |
A | GLU164 | |
A | GLY141 | |
A | GLU144 |
site_id | CSA10 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
D | GLY172 | |
D | GLU164 |
site_id | CSA11 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
E | GLY172 | |
E | GLU164 |
site_id | CSA12 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
F | GLY172 | |
F | GLU164 |
site_id | CSA13 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
A | GLU164 | |
A | GLY141 | |
A | GLU144 |
site_id | CSA14 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
B | GLU164 | |
B | GLY141 | |
B | GLU144 |
site_id | CSA15 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
C | GLU164 | |
C | GLY141 | |
C | GLU144 |
site_id | CSA16 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
D | GLU164 | |
D | GLY141 | |
D | GLU144 |
site_id | CSA17 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
E | GLU164 | |
E | GLY141 | |
E | GLU144 |
site_id | CSA18 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
F | GLU164 | |
F | GLY141 | |
F | GLU144 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
B | ALA98 | |
B | GLU164 | |
B | GLY141 | |
B | GLU144 |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
C | ALA98 | |
C | GLU164 | |
C | GLY141 | |
C | GLU144 |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
D | ALA98 | |
D | GLU164 | |
D | GLY141 | |
D | GLU144 |
site_id | CSA5 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
E | ALA98 | |
E | GLU164 | |
E | GLY141 | |
E | GLU144 |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
F | ALA98 | |
F | GLU164 | |
F | GLY141 | |
F | GLU144 |
site_id | CSA7 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
A | GLY172 | |
A | GLU164 |
site_id | CSA8 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
B | GLY172 | |
B | GLU164 |
site_id | CSA9 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dub |
Chain | Residue | Details |
C | GLY172 | |
C | GLU164 |