2HVL
Crystal structure of the HePTP catalytic domain C270S mutant
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein phosphatase non-receptor type 7 | polymer | 309 | 35319.9 | 1 | UniProt (P35236) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase LC-PTP, Hematopoietic protein-tyrosine phosphatase, HEPTP |
2 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence modifications
A: 44 - 339 (UniProt: P35236)
PDB | External Database | Details |
---|---|---|
Met -13 | - | cloning artifact |
Gly -12 | - | cloning artifact |
Ser -11 | - | cloning artifact |
Asp -10 | - | cloning artifact |
Lys -9 | - | cloning artifact |
Ile -8 | - | cloning artifact |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Met -1 | - | cloning artifact |
Ser 270 | Cys 291 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35319.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 282.0 | |
All* | Total formula weight | 35602.0 |