2HVL
Crystal structure of the HePTP catalytic domain C270S mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 7 | polymer | 309 | 35319.9 | 1 | UniProt (P35236) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase LC-PTP, Hematopoietic protein-tyrosine phosphatase, HEPTP |
| 2 | B, C (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 3 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | E (A) | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence modifications
A: 44 - 339 (UniProt: P35236)
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | cloning artifact |
| Gly -12 | - | cloning artifact |
| Ser -11 | - | cloning artifact |
| Asp -10 | - | cloning artifact |
| Lys -9 | - | cloning artifact |
| Ile -8 | - | cloning artifact |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| Met -1 | - | cloning artifact |
| Ser 270 | Cys 291 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35319.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 282.0 | |
| All* | Total formula weight | 35602.0 |
