2HRE
Structure of human ferrochelatase variant E343K with protoporphyrin IX bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Ferrochelatase | polymer | 359 | 41178.5 | 4 | UniProt (P22830) Pfam (PF00762) | Homo sapiens (human) | Protoheme ferro-lyase, Heme synthetase |
| 2 | E, G, H, K, M... (A, B, C, D) | PROTOPORPHYRIN IX | non-polymer | 562.7 | 6 | Chemie (PP9) | |||
| 3 | F, J, L, P (A, B, C, D) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 4 | Chemie (FES) | |||
| 4 | I, O (B, D) | CHOLIC ACID | non-polymer | 408.6 | 2 | Chemie (CHD) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 338 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 65 - 423 (UniProt: P22830)
| PDB | External Database | Details |
|---|---|---|
| Lys 343 | Glu 343 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 164713.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4896.4 | |
| All* | Total formula weight | 169610.2 |
