2HR7
Insulin receptor (domains 1-3)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Insulin receptor | polymer | 486 | 55544.7 | 2 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) In PDB | Homo sapiens (human) | |
| 2 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 3 | D, I | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G56014GC) | |||
| 4 | E | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 5 | F, K | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 2 | In PDB GlyTouCan (G32152BH) | |||
| 6 | G, H, L, M | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 4 | In PDB GlyTouCan (G21290RB) | |||
| 7 | J | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G55220VL) | |||
| 8 | B, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 9 | B, A | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 10 | A | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL | non-polymer | 326.4 | 1 | Chemie (P33) | |||
| 11 | A, B | GLYCEROL | non-polymer | 92.1 | 19 | Chemie (GOL) | |||
| 12 | water | water | 18.0 | 371 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 485 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| His 144 | Tyr 171 | variant |
| Ile 421 | Thr 448 | variant |
| Ser 486 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111089.4 | |
| Branched | Number of molecules | 11 |
| Total formula weight | 8139.5 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 3729.5 | |
| All* | Total formula weight | 122958.4 |
