2HGW
Crystal structure of Cys318Ala mutant of human mitochondrial branched chain aminotransferase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Branched-chain-amino-acid aminotransferase, mitochondrial | polymer | 365 | 41336.0 | 2 | UniProt (O15382) Pfam (PF01063) | Homo sapiens (human) | BCATm, Placental protein 18, PP18, Mitochondrial Branched Chain Aminotransferase |
| 2 | C, O (A, B) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 2 | Chemie (PLP) | |||
| 3 | D (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 4 | E, F, G, H, I... (A, B) | ACETIC ACID | non-polymer | 60.1 | 10 | Chemie (ACY) | |||
| 5 | M (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | N (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | R, S (A, B) | water | water | 18.0 | 172 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 365 (UniProt: O15382)
| PDB | External Database | Details |
|---|---|---|
| Arg 159 | Thr 186 | conflict |
| Ala 318 | Cys 345 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82671.9 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1521.3 | |
| All* | Total formula weight | 84193.2 |
