2HE0
Crystal structure of a human Notch1 ankyrin domain mutant
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Notch1 preproprotein variant | polymer | 253 | 27634.7 | 2 | UniProt (P46531) Pfam (PF00023) Pfam (PF12796) In PDB | Homo sapiens (human) | Human Notch ankyrin domain mutant |
2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
3 | water | water | 18.0 | 416 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 243 (UniProt: P46531)
PDB | External Database | Details |
---|---|---|
Ala 58 | Glu 1930 | engineered mutation |
Ala 66 | Arg 1938 | engineered mutation |
Leu 244 | - | cloning artifact |
Glu 245 | - | cloning artifact |
His 246 | - | expression tag |
His 247 | - | expression tag |
His 248 | - | expression tag |
His 249 | - | expression tag |
His 250 | - | expression tag |
His 251 | - | expression tag |
His 252 | - | expression tag |
His 253 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 55269.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 62.1 | |
All* | Total formula weight | 55331.4 |