2HDV
Crystal structure of the Src Homology-2 domain of the adapter protein SH2-B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | SH2-B PH domain containing signaling mediator 1 gamma isoform | polymer | 111 | 12276.0 | 2 | UniProt (Q9WVM5) Pfam (PF00017) UniProt (by SIFTS) (Q91ZM2) In PDB | Mus musculus (house mouse) | |
| 2 | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
A, B: 519 - 627 (UniProt: Q9WVM5)
| PDB | External Database | Details |
|---|---|---|
| Gly 517 | - | cloning artifact |
| Ser 518 | - | cloning artifact |
| Ala 583 | Glu 563 | engineered mutation |
| Ala 584 | Glu 564 | engineered mutation |
| His 593 | Trp 573 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24552.0 | |
| All* | Total formula weight | 24552.0 |
