2HDV

Crystal structure of the Src Homology-2 domain of the adapter protein SH2-B

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	SH2-B PH domain containing signaling mediator 1 gamma isoform	polymer	111	12276.0	2	UniProt (Q9WVM5) Pfam (PF00017) UniProt (by SIFTS) (Q91ZM2)	Mus musculus (house mouse)
2	C, D (A, B)	water	water		18.0	131	Chemie (HOH)

Sequence modifications

A, B: 519 - 627 (UniProt: Q9WVM5)

PDB	External Database	Details
Gly 517	-	cloning artifact
Ser 518	-	cloning artifact
Ala 583	Glu 563	engineered mutation
Ala 584	Glu 564	engineered mutation
His 593	Trp 573	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	24552.0
All*	Total formula weight	24552.0

*Water molecules are not included.