2HC0
Structure of HIV protease 6X mutant in complex with AB-2.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Protease | polymer | 99 | 10749.7 | 2 | UniProt (P03367) Pfam (PF00077) UniProt (by SIFTS) (Q9E3M8) In PDB | Human immunodeficiency virus 1 | |
| 2 | A, B | BROMIDE ION | non-polymer | 79.9 | 12 | Chemie (BR) | |||
| 3 | A | [1-((1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL (1R,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YLCARBAMATE | non-polymer | 663.8 | 1 | Chemie (AB2) | |||
| 4 | water | water | 18.0 | 293 | Chemie (HOH) |
Sequence modifications
A, B: 1001 - 1099 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Lys 1007 | Gln 506 | engineered mutation |
| Ile 1024 | Leu 523 | engineered mutation |
| Ile 1046 | Met 545 | engineered mutation |
| Leu 1053 | Phe 552 | engineered mutation |
| Pro 1063 | Leu 562 | engineered mutation |
| Ile 1077 | Val 576 | engineered mutation |
| Ala 1082 | Val 581 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21499.4 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1622.6 | |
| All* | Total formula weight | 23122.0 |
