2HBL
Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain; Protein in complex with Mn, Zn, and AMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Exosome complex exonuclease RRP6 | polymer | 410 | 47675.1 | 1 | UniProt (Q12149) Pfam (PF01612) Pfam (PF00570) | Saccharomyces cerevisiae (baker's yeast) | Ribosomal RNA- processing protein 6 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 4 | D (A) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) | |||
| 5 | E (A) | water | water | 18.0 | 127 | Chemie (HOH) |
Sequence modifications
A: 129 - 536 (UniProt: Q12149)
| PDB | External Database | Details |
|---|---|---|
| Gly 127 | - | cloning artifact |
| Met 128 | - | cloning artifact |
| Ala 361 | Tyr 361 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 47675.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 467.6 | |
| All* | Total formula weight | 48142.7 |
