2H31
Crystal structure of human PAICS, a bifunctional carboxylase and synthetase in purine biosynthesis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Multifunctional protein ADE2 | polymer | 425 | 47463.4 | 1 | UniProt (P22234) Pfam (PF01259) Pfam (PF00731) In PDB | Homo sapiens (human) | Phosphoribosylaminoimidazole-succinocarboxamide synthase, Phosphoribosylaminoimidazole carboxylase |
| 2 | A | CARBON DIOXIDE | non-polymer | 44.0 | 1 | Chemie (CO2) | |||
| 3 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 2 - 425 (UniProt: P22234)
| PDB | External Database | Details |
|---|---|---|
| Mse 1 | - | INITIATING METHIONINE |
| Mse 93 | Met 92 | MODIFIED RESIDUE |
| Mse 165 | Met 164 | MODIFIED RESIDUE |
| Mse 190 | Met 189 | MODIFIED RESIDUE |
| Mse 244 | Met 243 | MODIFIED RESIDUE |
| Mse 272 | Met 271 | MODIFIED RESIDUE |
| Mse 339 | Met 338 | MODIFIED RESIDUE |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 47463.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 44.0 | |
| All* | Total formula weight | 47507.4 |
