2H2G
The Structural Basis of Sirtuin substrate affinity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent deacetylase | polymer | 246 | 27569.8 | 1 | UniProt (Q9WYW0) Pfam (PF02146) | Thermotoga maritima | Regulatory protein SIR2 homolog |
| 2 | B (B) | HISTONE H3 PEPTIDE | polymer | 11 | 1369.6 | 1 | UniProt (P61830) | ||
| 3 | C, D (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 286 | Chemie (HOH) |
Sequence modifications
B: 113 - 123 (UniProt: P61830)
| PDB | External Database | Details |
|---|---|---|
| Thr 118 | Ala 29 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28939.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 29070.2 |
