2H08

crystal structure of human phosphoribosyl pyrophosphate synthetase 1 mutant Y146M

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Ribose-phosphate pyrophosphokinase I	polymer	326	35918.4	2	UniProt (P60891) Pfam (PF13793) Pfam (PF14572) In PDB	Homo sapiens (human)	Phosphoribosyl pyrophosphate synthetase I, PRS-I, PPRibP, PRPP synthetase 1
2	A, B	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
3		water	water		18.0	164	Chemie (HOH)

Sequence modifications

A, B: 1 - 318 (UniProt: P60891)

PDB	External Database	Details
Met 146	Tyr 146	engineered mutation
Leu 319	-	expression tag
Glu 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71836.8
Non-Polymers*	Number of molecules	6
	Total formula weight	576.4
All*	Total formula weight	72413.2

*Water molecules are not included.