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2H08

crystal structure of human phosphoribosyl pyrophosphate synthetase 1 mutant Y146M

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0002189cellular_componentribose phosphate diphosphokinase complex
A0004749molecular_functionribose phosphate diphosphokinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006015biological_process5-phosphoribose 1-diphosphate biosynthetic process
A0006144biological_processpurine nucleobase metabolic process
A0006164biological_processpurine nucleotide biosynthetic process
A0006221biological_processpyrimidine nucleotide biosynthetic process
A0006796biological_processphosphate-containing compound metabolic process
A0007399biological_processnervous system development
A0009156biological_processribonucleoside monophosphate biosynthetic process
A0009165biological_processnucleotide biosynthetic process
A0016301molecular_functionkinase activity
A0034418biological_processurate biosynthetic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0044249biological_processcellular biosynthetic process
A0046101biological_processhypoxanthine biosynthetic process
A0046872molecular_functionmetal ion binding
A0090407biological_processorganophosphate biosynthetic process
B0000287molecular_functionmagnesium ion binding
B0002189cellular_componentribose phosphate diphosphokinase complex
B0004749molecular_functionribose phosphate diphosphokinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006015biological_process5-phosphoribose 1-diphosphate biosynthetic process
B0006144biological_processpurine nucleobase metabolic process
B0006164biological_processpurine nucleotide biosynthetic process
B0006221biological_processpyrimidine nucleotide biosynthetic process
B0006796biological_processphosphate-containing compound metabolic process
B0007399biological_processnervous system development
B0009156biological_processribonucleoside monophosphate biosynthetic process
B0009165biological_processnucleotide biosynthetic process
B0016301molecular_functionkinase activity
B0034418biological_processurate biosynthetic process
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0044249biological_processcellular biosynthetic process
B0046101biological_processhypoxanthine biosynthetic process
B0046872molecular_functionmetal ion binding
B0090407biological_processorganophosphate biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 B 1001
ChainResidue
BASP224
BTHR225
BCYS226
BGLY227
BTHR228
BHOH1061

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 1002
ChainResidue
AGLY227
ATHR228
AHOH1072
AHOH1074
AASP224
ATHR225
ACYS226

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 1003
ChainResidue
AARG104
BSER47
BARG49
BSER308
BVAL309
BSER310
BHOH1045

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 1004
ChainResidue
ASER47
AARG49
ASER308
AVAL309
ASER310
AHOH1014
AHOH1034
BARG104

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 B 1005
ChainResidue
ALYS100
AASP101
ALYS102
BSER132
BGLN135
BASN144
BHOH1007
BHOH1082

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 1006
ChainResidue
ASER132
AGLN135
AASN144
AHOH1020
AHOH1079
BLYS100
BASP101
BLYS102

Functional Information from PROSITE/UniProt
site_idPS00114
Number of Residues16
DetailsPRPP_SYNTHASE Phosphoribosyl pyrophosphate synthase signature. DLHAsQIQGFFdiPVD
ChainResidueDetails
AASP128-ASP143

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING:
ChainResidueDetails
AARG96
BARG96

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255
ChainResidueDetails
AASP128
AHIS130
AASP139
AASP143
BASP128
BHIS130
BASP139
BASP143

222415

PDB entries from 2024-07-10

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