2GY7
Angiopoietin-2/Tie2 Complex Crystal Structure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Angiopoietin-2 | polymer | 216 | 24752.5 | 1 | UniProt (O15123) Pfam (PF00147) In PDB | Homo sapiens (human) | ANG-2 |
| 2 | B | Angiopoietin-1 receptor | polymer | 423 | 47186.1 | 1 | UniProt (Q02763) Pfam (PF10430) In PDB | Homo sapiens (human) | Tyrosine-protein kinase receptor TIE-2, hTIE2, Tyrosine-protein kinase receptor TEK, p140 TEK, Tunica interna endothelial cell kinase, CD202b antigen |
| 3 | C | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 830.8 | 1 | In PDB GlyTouCan (G79211JZ) | |||
| 4 | D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 5 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) |
Sequence modifications
A: 281 - 495 (UniProt: O15123)
| PDB | External Database | Details |
|---|---|---|
| Glu 280 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71938.7 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1679.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 453.4 | |
| All* | Total formula weight | 74071.7 |
