2GPH

Docking motif interactions in the MAP kinase ERK2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Mitogen-activated protein kinase 1	polymer	364	42161.5	1	UniProt (P63086) Pfam (PF00069)	Rattus norvegicus (Norway rat)	Extracellular signal-regulated kinase 2, ERK-2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1
2	B (B)	Tyrosine-protein phosphatase non-receptor type 7	polymer	16	1864.2	1	UniProt (P35236)		Protein-tyrosine phosphatase LC-PTP, Hematopoietic protein-tyrosine phosphatase, HEPTP
3	C, D (A, B)	water	water		18.0	290	Chemie (HOH)

Sequence modifications

A: 2 - 358 (UniProt: P63086)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Met 1	-	cloning artifact
Cys 116	Thr 115	engineered mutation

B: 16 - 31 (UniProt: P35236)

PDB	External Database	Details
Cys 31	Val 52	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	44025.7
All*	Total formula weight	44025.7

*Water molecules are not included.