2GP9
Crystal structure of the slow form of thrombin in a self-inhibited conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Prothrombin | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 2 | B (B) | Prothrombin | polymer | 259 | 29779.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 3 | C (B) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence modifications
B: 16 - 245 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Asn 102 | Asp 462 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33875.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 238.3 | |
| All* | Total formula weight | 34114.1 |
