2GJJ
Crystal structure of a single chain antibody scA21 against Her2/ErbB2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | A21 single-chain antibody fragment against erbB2 | polymer | 264 | 28366.1 | 2 | GenBank (19698754) GenBank (19698750) | Mus musculus (house mouse) | anti-p185/HER2 immunoglobulin kappa light chain variable region, anit-p185/HER2 immunoglobulin gamma heavy chain variable region |
2 | A, B | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
3 | water | water | 18.0 | 396 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 114 (GenBank: 19698754)
A, B: 135 - 254 (GenBank: 19698750)
PDB | External Database | Details |
---|---|---|
Glu -3 | - | expression tag |
Ala -2 | - | expression tag |
Glu -1 | - | expression tag |
Ala 0 | - | expression tag |
Gly 115 | - | linker |
Gly 116 | - | linker |
Gly 117 | - | linker |
Gly 118 | - | linker |
Ser 119 | - | linker |
Gly 120 | - | linker |
Gly 121 | - | linker |
Gly 122 | - | linker |
Gly 123 | - | linker |
Ser 124 | - | linker |
Gly 125 | - | linker |
Gly 126 | - | linker |
Gly 127 | - | linker |
Gly 128 | - | linker |
Ser 129 | - | linker |
Gly 130 | - | linker |
Gly 131 | - | linker |
Gly 132 | - | linker |
Gly 133 | - | linker |
Ser 134 | - | linker |
His 255 | - | expression tag |
His 256 | - | expression tag |
His 257 | - | expression tag |
His 258 | - | expression tag |
His 259 | - | expression tag |
His 260 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Leu 138 | Val 4 | conflict |
Asp 227 | Val 93 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 56732.2 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 552.6 | |
All* | Total formula weight | 57284.8 |