2GJJ

Crystal structure of a single chain antibody scA21 against Her2/ErbB2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	A21 single-chain antibody fragment against erbB2	polymer	264	28366.1	2	GenBank (19698754) GenBank (19698750)	Mus musculus (house mouse)	anti-p185/HER2 immunoglobulin kappa light chain variable region, anit-p185/HER2 immunoglobulin gamma heavy chain variable region
2	C, D, E, F, G... (A, B)	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
3	I, J (A, B)	water	water		18.0	396	Chemie (HOH)

Sequence modifications

A, B: 1 - 114 (GenBank: 19698754)

PDB	External Database	Details
Glu -3	-	expression tag
Ala -2	-	expression tag
Glu -1	-	expression tag
Ala 0	-	expression tag
Gly 115	-	linker
Gly 116	-	linker
Gly 117	-	linker
Gly 118	-	linker
Ser 119	-	linker
Gly 120	-	linker
Gly 121	-	linker
Gly 122	-	linker
Gly 123	-	linker
Ser 124	-	linker
Gly 125	-	linker
Gly 126	-	linker
Gly 127	-	linker
Gly 128	-	linker
Ser 129	-	linker
Gly 130	-	linker
Gly 131	-	linker
Gly 132	-	linker
Gly 133	-	linker
Ser 134	-	linker
His 255	-	expression tag
His 256	-	expression tag
His 257	-	expression tag
His 258	-	expression tag
His 259	-	expression tag
His 260	-	expression tag

A, B: 135 - 254 (GenBank: 19698750)

PDB	External Database	Details
Leu 138	Val 4	conflict
Asp 227	Val 93	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	56732.2
Non-Polymers*	Number of molecules	6
	Total formula weight	552.6
All*	Total formula weight	57284.8

*Water molecules are not included.