2GIX
Cytoplasmic Domain Structure of Kir2.1 containing Andersen's Mutation R218Q and Rescue Mutation T309K
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Inward rectifier potassium channel 2 | polymer | 208 | 23908.2 | 4 | UniProt (P35561) Pfam (PF17655) | Mus musculus (house mouse) | Potassium channel, inwardly rectifying subfamily J member 2, Inward rectifier K+, channel Kir2.1 |
| 2 | E (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 3 | F, G, H, I (A, B, C, D) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 4 | Chemie (MPD) | |||
| 4 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 700 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 189 - 371 (UniProt: P35561)
A, B, C, D: 44 - 64 (UniProt: P35561)
| PDB | External Database | Details |
|---|---|---|
| Gln 218 | Arg 218 | engineered mutation |
| Lys 309 | Thr 309 | engineered mutation |
| Gly 40 | - | cloning artifact |
| Ser 41 | - | cloning artifact |
| His 42 | - | cloning artifact |
| Gly 43 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 95632.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 511.8 | |
| All* | Total formula weight | 96144.6 |
