2GC8
Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | RNA-directed RNA polymerase | polymer | 578 | 64247.6 | 2 | UniProt (Q99AU2) Pfam (PF00998) In PDB | Hepatitis C virus | |
2 | A, B | 1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE | non-polymer | 318.8 | 2 | Chemie (885) | |||
3 | water | water | 18.0 | 478 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 570 (UniProt: Q99AU2)
PDB | External Database | Details |
---|---|---|
Gln 544 | Arg 2962 | variant |
Gly 571 | - | cloning artifact |
Ser 572 | - | cloning artifact |
His 573 | - | expression tag |
His 574 | - | expression tag |
His 575 | - | expression tag |
His 576 | - | expression tag |
His 577 | - | expression tag |
His 578 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 128495.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 637.6 | |
All* | Total formula weight | 129132.8 |