2GC8

Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	RNA-directed RNA polymerase	polymer	578	64247.6	2	UniProt (Q99AU2) Pfam (PF00998)	Hepatitis C virus
2	C, D (A, B)	1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE	non-polymer		318.8	2	Chemie (885)
3	E, F (A, B)	water	water		18.0	478	Chemie (HOH)

Sequence modifications

A, B: 1 - 570 (UniProt: Q99AU2)

PDB	External Database	Details
Gln 544	Arg 2962	variant
Gly 571	-	cloning artifact
Ser 572	-	cloning artifact
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag
His 576	-	expression tag
His 577	-	expression tag
His 578	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	128495.2
Non-Polymers*	Number of molecules	2
	Total formula weight	637.6
All*	Total formula weight	129132.8

*Water molecules are not included.