2GC8
Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| B | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 885 B 579 |
| Chain | Residue |
| B | ARG200 |
| B | HOH729 |
| B | HOH733 |
| B | HOH810 |
| B | CYS366 |
| B | LEU384 |
| B | MET414 |
| B | TYR415 |
| B | GLN446 |
| B | ILE447 |
| B | TYR448 |
| B | GLY449 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 885 A 579 |
| Chain | Residue |
| A | ARG200 |
| A | CYS366 |
| A | LEU384 |
| A | MET414 |
| A | TYR415 |
| A | GLN446 |
| A | ILE447 |
| A | TYR448 |
| A | GLY449 |
| A | HOH761 |
| A | HOH811 |
