2G50
The location of the allosteric amino acid binding site of muscle pyruvate kinase.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Pyruvate kinase isozymes M1/M2 | polymer | 530 | 57970.8 | 8 | UniProt (P11974) Pfam (PF00224) Pfam (PF02887) | Oryctolagus cuniculus (rabbit) | Pyruvate kinase muscle isozyme |
| 2 | EB, GC, HA, I, QC... (E, G, C, A, H...) | MANGANESE (II) ION | non-polymer | 54.9 | 8 | Chemie (MN) | |||
| 3 | FB, HC, IA, J, RC... (E, G, C, A, H...) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
| 4 | GB, HB, IC, JA, K... (E, G, C, A, H...) | SODIUM ION | non-polymer | 23.0 | 12 | Chemie (NA) | |||
| 5 | IB, JC, KA, M, UC... (E, G, C, A, H...) | ALANINE | non-polymer | 89.1 | 8 | Chemie (ALA) | |||
| 6 | JB, KC, LA, N, VC... (E, G, C, A, H...) | PYRUVIC ACID | non-polymer | 88.1 | 8 | Chemie (PYR) | |||
| 7 | AA, AB, AD, BA, BB... (B, D, H, E, G...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 29 | Chemie (EDO) | |||
| 8 | AC, BC, CB, CC, CD... (F, D, H, B, G...) | GLYCEROL | non-polymer | 92.1 | 28 | Chemie (GOL) | |||
| 9 | DA (B) | 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL | non-polymer | 208.3 | 1 | Chemie (ETE) | |||
| 10 | GD, HD, ID, JD, KD... (A, B, C, D, E...) | water | water | 18.0 | 4794 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 530 (UniProt: P11974)
| PDB | External Database | Details |
|---|---|---|
| Lys 29 | Met 29 | SEE REMARK 999 |
| Ala 400 | Ser 400 | SEE REMARK 999 |
| Gln 403 | His 403 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 463766.3 | |
| Non-Polymers* | Number of molecules | 102 |
| Total formula weight | 7032.3 | |
| All* | Total formula weight | 470798.6 |
