Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2G50

The location of the allosteric amino acid binding site of muscle pyruvate kinase.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003729	molecular_function	mRNA binding
A	0003824	molecular_function	catalytic activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
A	0004743	molecular_function	pyruvate kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005791	cellular_component	rough endoplasmic reticulum
A	0006096	biological_process	glycolytic process
A	0006417	biological_process	regulation of translation
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0030955	molecular_function	potassium ion binding
A	0046872	molecular_function	metal ion binding
A	1903672	biological_process	positive regulation of sprouting angiogenesis
A	2000767	biological_process	positive regulation of cytoplasmic translation
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003729	molecular_function	mRNA binding
B	0003824	molecular_function	catalytic activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
B	0004743	molecular_function	pyruvate kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005791	cellular_component	rough endoplasmic reticulum
B	0006096	biological_process	glycolytic process
B	0006417	biological_process	regulation of translation
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0030955	molecular_function	potassium ion binding
B	0046872	molecular_function	metal ion binding
B	1903672	biological_process	positive regulation of sprouting angiogenesis
B	2000767	biological_process	positive regulation of cytoplasmic translation
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0003729	molecular_function	mRNA binding
C	0003824	molecular_function	catalytic activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
C	0004743	molecular_function	pyruvate kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005791	cellular_component	rough endoplasmic reticulum
C	0006096	biological_process	glycolytic process
C	0006417	biological_process	regulation of translation
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0030955	molecular_function	potassium ion binding
C	0046872	molecular_function	metal ion binding
C	1903672	biological_process	positive regulation of sprouting angiogenesis
C	2000767	biological_process	positive regulation of cytoplasmic translation
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003729	molecular_function	mRNA binding
D	0003824	molecular_function	catalytic activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
D	0004743	molecular_function	pyruvate kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005791	cellular_component	rough endoplasmic reticulum
D	0006096	biological_process	glycolytic process
D	0006417	biological_process	regulation of translation
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0030955	molecular_function	potassium ion binding
D	0046872	molecular_function	metal ion binding
D	1903672	biological_process	positive regulation of sprouting angiogenesis
D	2000767	biological_process	positive regulation of cytoplasmic translation
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0003729	molecular_function	mRNA binding
E	0003824	molecular_function	catalytic activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004713	molecular_function	protein tyrosine kinase activity
E	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
E	0004743	molecular_function	pyruvate kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005791	cellular_component	rough endoplasmic reticulum
E	0006096	biological_process	glycolytic process
E	0006417	biological_process	regulation of translation
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0030955	molecular_function	potassium ion binding
E	0046872	molecular_function	metal ion binding
E	1903672	biological_process	positive regulation of sprouting angiogenesis
E	2000767	biological_process	positive regulation of cytoplasmic translation
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0003729	molecular_function	mRNA binding
F	0003824	molecular_function	catalytic activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0004713	molecular_function	protein tyrosine kinase activity
F	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
F	0004743	molecular_function	pyruvate kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005791	cellular_component	rough endoplasmic reticulum
F	0006096	biological_process	glycolytic process
F	0006417	biological_process	regulation of translation
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0030955	molecular_function	potassium ion binding
F	0046872	molecular_function	metal ion binding
F	1903672	biological_process	positive regulation of sprouting angiogenesis
F	2000767	biological_process	positive regulation of cytoplasmic translation
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0003729	molecular_function	mRNA binding
G	0003824	molecular_function	catalytic activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0004713	molecular_function	protein tyrosine kinase activity
G	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
G	0004743	molecular_function	pyruvate kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005791	cellular_component	rough endoplasmic reticulum
G	0006096	biological_process	glycolytic process
G	0006417	biological_process	regulation of translation
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0030955	molecular_function	potassium ion binding
G	0046872	molecular_function	metal ion binding
G	1903672	biological_process	positive regulation of sprouting angiogenesis
G	2000767	biological_process	positive regulation of cytoplasmic translation
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0003729	molecular_function	mRNA binding
H	0003824	molecular_function	catalytic activity
H	0004674	molecular_function	protein serine/threonine kinase activity
H	0004713	molecular_function	protein tyrosine kinase activity
H	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
H	0004743	molecular_function	pyruvate kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005791	cellular_component	rough endoplasmic reticulum
H	0006096	biological_process	glycolytic process
H	0006417	biological_process	regulation of translation
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0030955	molecular_function	potassium ion binding
H	0046872	molecular_function	metal ion binding
H	1903672	biological_process	positive regulation of sprouting angiogenesis
H	2000767	biological_process	positive regulation of cytoplasmic translation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 640

Chain	Residue
A	GLU271
A	ASP295
A	PYR600
A	HOH6777
A	HOH6778

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 6501

Chain	Residue
A	HOH6776
A	HOH6779
A	ASN74
A	SER76
A	ASP112
A	THR113

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN B 640

Chain	Residue
B	GLU271
B	ASP295
B	PYR600
B	HOH6929
B	HOH6930

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K B 6502

Chain	Residue
B	ASN74
B	SER76
B	ASP112
B	THR113
B	SER242
B	HOH6928
B	HOH6931

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C 640

Chain	Residue
C	GLU271
C	ASP295
C	PYR600
C	HOH6693
C	HOH6694

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K C 6503

Chain	Residue
C	ASN74
C	SER76
C	ASP112
C	THR113
C	SER242
C	HOH6692
C	HOH6695

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN D 640

Chain	Residue
D	GLU271
D	ASP295
D	PYR600
D	HOH7070
D	HOH7073

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K D 6504

Chain	Residue
D	ASN74
D	SER76
D	ASP112
D	THR113
D	SER242
D	HOH7071
D	HOH7072

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN E 640

Chain	Residue
E	GLU271
E	ASP295
E	PYR600
E	HOH3432
E	HOH3433

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 6505

Chain	Residue
E	ASN74
E	SER76
E	ASP112
E	THR113
E	HOH3431
E	HOH3434

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN F 640

Chain	Residue
F	GLU271
F	ASP295
F	PYR600
F	HOH6523
F	HOH6825

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K F 6506

Chain	Residue
F	ASN74
F	SER76
F	ASP112
F	THR113
F	SER242
F	HOH6524
F	HOH6824

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN G 640

Chain	Residue
G	GLU271
G	ASP295
G	PYR600
G	HOH2776
G	HOH2777

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K G 6507

Chain	Residue
G	ASN74
G	SER76
G	ASP112
G	THR113
G	SER242
G	HOH2775
G	HOH2778

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN H 640

Chain	Residue
H	GLU271
H	ASP295
H	PYR600
H	HOH6673
H	HOH6674

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K H 6508

Chain	Residue
H	ASN74
H	SER76
H	ASP112
H	THR113
H	HOH6672
H	HOH6675

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 6019

Chain	Residue
A	HOH7007
A	LYS124
A	GLY125
A	SER126
A	GLY127
A	THR128
A	HOH7006

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 6020

Chain	Residue
D	LYS124
D	GLY125
D	SER126
D	GLY127
D	THR128
D	HOH6753

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA E 6021

Chain	Residue
E	LYS124
E	GLY125
E	SER126
E	GLY127
E	THR128
E	HOH4539

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA H 6022

Chain	Residue
H	LYS124
H	GLY125
H	SER126
H	GLY127
H	THR128
H	HOH6510
H	HOH6745

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 6023

Chain	Residue
A	THR431
A	SER436
A	HOH6812

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA B 6024

Chain	Residue
B	THR431
B	SER436
B	HOH6556

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA C 6025

Chain	Residue
C	THR431
C	SER436
C	HOH6628

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA D 6026

Chain	Residue
D	THR431
D	SER436
D	HOH6516

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA F 6027

Chain	Residue
F	THR431
F	SER436
F	HOH6754

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA G 6028

Chain	Residue
G	THR431
G	SER436
G	HOH3003

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA H 6029

Chain	Residue
H	THR431
H	SER436
H	HOH6625

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA E 6030

Chain	Residue
E	THR431
E	SER436
E	HOH4160

site_id	DC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ALA A 6101

Chain	Residue
A	ARG42
A	ASN43
A	ASN69
A	ARG105
A	HIS463
A	ILE468
A	PHE469
A	PRO470
A	HOH6548
A	HOH6549
A	HOH7059

site_id	DC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PYR A 600

Chain	Residue
A	LYS269
A	GLU271
A	ALA292
A	ARG293
A	GLY294
A	ASP295
A	THR327
A	MN640
A	HOH6776
A	HOH6777
A	HOH6778

site_id	DC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ALA B 6102

Chain	Residue
B	ARG42
B	ASN43
B	ASN69
B	HIS463
B	ILE468
B	PHE469
B	PRO470
B	EDO6032
B	HOH6758
B	HOH6765
B	HOH6766

site_id	DC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PYR B 600

Chain	Residue
B	LYS269
B	GLU271
B	ALA292
B	ARG293
B	GLY294
B	ASP295
B	THR327
B	MN640
B	HOH6928
B	HOH6929
B	HOH6930

site_id	DC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ALA C 6103

Chain	Residue
C	ARG42
C	ASN43
C	ASN69
C	ARG105
C	HIS463
C	ILE468
C	PHE469
C	PRO470
C	HOH6535
C	HOH6547
C	HOH7053

site_id	DC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PYR C 600

Chain	Residue
C	LYS269
C	GLU271
C	ALA292
C	ARG293
C	GLY294
C	ASP295
C	THR327
C	MN640
C	HOH6692
C	HOH6693
C	HOH6694

site_id	DC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ALA D 6104

Chain	Residue
D	ARG42
D	ASN43
D	ASN69
D	ARG105
D	HIS463
D	ILE468
D	PHE469
D	PRO470
D	HOH6995
D	HOH6998
D	HOH7124

site_id	DC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PYR D 600

Chain	Residue
D	LYS269
D	GLU271
D	ALA292
D	ARG293
D	GLY294
D	ASP295
D	THR327
D	MN640
D	EDO6033
D	HOH7070
D	HOH7072
D	HOH7073

site_id	EC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ALA E 6105

Chain	Residue
E	ARG42
E	ASN43
E	ASN69
E	ARG105
E	HIS463
E	ILE468
E	PHE469
E	PRO470
E	HOH3633
E	HOH3634
E	HOH4515
E	HOH4823

site_id	EC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PYR E 600

Chain	Residue
E	LYS269
E	GLU271
E	ALA292
E	ARG293
E	GLY294
E	ASP295
E	THR327
E	MN640
E	HOH3431
E	HOH3432
E	HOH3433

site_id	EC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ALA F 6106

Chain	Residue
F	ARG42
F	ASN43
F	ASN69
F	ARG105
F	HIS463
F	ILE468
F	PHE469
F	PRO470
F	HOH6646
F	HOH6647
F	HOH7014

site_id	EC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PYR F 600

Chain	Residue
F	LYS269
F	GLU271
F	ALA292
F	ARG293
F	GLY294
F	ASP295
F	THR327
F	MN640
F	GOL6057
F	HOH6523
F	HOH6524
F	HOH6825

site_id	EC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ALA G 6107

Chain	Residue
G	ARG42
G	ASN43
G	ASN69
G	ARG105
G	HIS463
G	ILE468
G	PHE469
G	PRO470
G	HOH3727
G	HOH3728
G	HOH4510

site_id	EC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PYR G 600

Chain	Residue
G	LYS269
G	GLU271
G	ALA292
G	ARG293
G	GLY294
G	ASP295
G	THR327
G	MN640
G	HOH2775
G	HOH2776
G	HOH2777

site_id	EC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ALA H 6108

Chain	Residue
H	ARG42
H	ASN43
H	ASN69
H	ARG105
H	HIS463
H	ILE468
H	PHE469
H	PRO470
H	HOH6893
H	HOH6894
H	HOH6960

site_id	EC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PYR H 600

Chain	Residue
H	LYS269
H	GLU271
H	ALA292
H	ARG293
H	GLY294
H	ASP295
H	THR327
H	MN640
H	EDO6041
H	HOH6672
H	HOH6673
H	HOH6674

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D 6011

Chain	Residue
D	PRO38
D	THR40
D	HOH6618

site_id	FC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO F 6012

Chain	Residue
F	PRO38
F	THR40
F	HOH6631
F	HOH6637

site_id	FC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 6013

Chain	Residue
B	PRO38
B	THR40
B	HOH6977

site_id	FC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 6014

Chain	Residue
C	PRO38
C	THR40
C	HOH6573

site_id	FC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO E 6015

Chain	Residue
E	PRO38
E	THR40
G	EDO6016

site_id	FC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO G 6016

Chain	Residue
E	ALA37
E	EDO6015
G	LYS304
G	HOH2692

site_id	FC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 6017

Chain	Residue
D	ARG72
D	ASN74
D	SER361
D	GLY362
D	HOH6676
D	HOH7072

site_id	FC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO B 6032

Chain	Residue
B	TYR104
B	ARG105
B	PRO106
B	HIS463
B	PHE469
B	PRO470
B	ARG499
B	ALA6102
B	HOH6755
B	HOH6758

site_id	FC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D 6033

Chain	Residue
D	ASP177
D	GLY294
D	PYR600

site_id	FC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO H 6034

Chain	Residue
H	ARG72
H	ASN74
H	SER361
H	HOH6667
H	HOH6668
H	HOH6772

site_id	GC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO F 6036

Chain	Residue
F	ARG338
F	PRO339
F	ARG341
F	HOH6514
H	ASP177
H	GLN328

site_id	GC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO H 6037

Chain	Residue
H	GLU284
H	ALA285
H	SER286
H	ASP287
H	LYS321
H	HOH6709
H	HOH7085

site_id	GC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 6038

Chain	Residue
E	ARG72
E	ASN74
E	SER361
E	GLY362
E	HOH3429
E	EDO6046

site_id	GC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO E 6039

Chain	Residue
E	ASP177

site_id	GC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D 6040

Chain	Residue
D	THR138
D	GLU153
D	ASN154

site_id	GC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO H 6041

Chain	Residue
H	ASP177
H	GLY294
H	ASP295
H	PYR600
H	HOH6525

site_id	GC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO H 6042

Chain	Residue
F	ARG318
H	GLU27
H	CYS30
H	HOH7076

site_id	GC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 6043

Chain	Residue
A	GLU95
A	TYR104
A	HIS456
A	ARG460
A	HOH6559
A	HOH6698
A	HOH6701
A	HOH7111

site_id	GC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 6044

Chain	Residue
A	ASP177
A	GLN328
C	PRO339
C	ARG341
C	HOH7078

site_id	HC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 6045

Chain	Residue
E	ARG55
E	TYR82
E	HOH2717
E	HOH5069
E	GOL6031
H	HOH6567

site_id	HC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO E 6046

Chain	Residue
E	ILE50
E	GLY51
E	ASN74
E	ALA365
E	LYS366
E	HOH3458
E	EDO6038

site_id	HC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 6047

Chain	Residue
B	ARG254
B	GLU284
B	ALA285
B	SER286
B	ASP287
B	LYS321
B	HOH6897
B	HOH7013

site_id	HC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 6048

Chain	Residue
B	ASP177
B	GLY294
B	ASP295
B	GOL6302
B	HOH6922
B	HOH6924
B	HOH7001
B	HOH7009

site_id	HC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO E 6049

Chain	Residue
E	GLU284
E	ALA285
E	SER286
E	LYS321
E	HOH3355
E	HOH4836
E	HOH4961

site_id	HC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 6050

Chain	Residue
A	GLU284
A	ALA285
A	SER286
A	ASP287
A	LYS321
A	HOH7107
A	HOH7115
A	HOH7120

site_id	HC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 6051

Chain	Residue
A	ARG338
A	PRO339
A	THR340
A	ARG341
A	HOH7048
C	ASP177
C	LEU179
C	GLN328

site_id	HC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO G 6052

Chain	Residue
G	ARG42
G	LYS65
G	SER66
G	GLY67
G	HOH3479
G	HOH3726
G	HOH3729

site_id	HC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO H 6053

Chain	Residue
H	GLU58
H	LYS61
H	HOH6652

site_id	IC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO H 6054

Chain	Residue
E	GOL6031
H	PRO52
H	ALA53
H	SER54
H	ARG55
H	SER56
H	THR59
H	HOH6660

site_id	IC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ETE B 6018

Chain	Residue
B	THR49
B	ILE50
B	GLY51
B	PRO52
B	ARG72
B	ASN74
B	ALA365
B	LYS366
B	HOH6655
B	HOH6928
B	HOH6954
B	HOH7011

site_id	IC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 6201

Chain	Residue
A	PRO116
A	ASN209
A	LEU210
A	VAL215
A	ARG245
A	GLU299
A	HOH6657
A	HOH6658

site_id	IC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 6301

Chain	Residue
A	GLU117
A	ILE118
A	GLY207
A	VAL208
A	PHE243
A	ASP295
A	HOH6755
A	HOH6777

site_id	IC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 6202

Chain	Residue
B	PRO116
B	ASN209
B	LEU210
B	VAL215
B	ARG245
B	GLU299
B	HOH6613
B	HOH6614
B	HOH6615

site_id	IC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 6302

Chain	Residue
B	GLU117
B	ILE118
B	GLY207
B	VAL208
B	PHE243
B	ASP295
B	EDO6048
B	HOH6924
B	HOH6929

site_id	IC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 6203

Chain	Residue
C	PRO116
C	VAL208
C	ASN209
C	LEU210
C	VAL215
C	ARG245
C	GLU299
C	HOH6865

site_id	IC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 6303

Chain	Residue
C	GLU117
C	ILE118
C	GLY207
C	VAL208
C	PHE243
C	ASP295
C	HOH6693

site_id	IC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 6204

Chain	Residue
D	PRO116
D	ASN209
D	LEU210
D	VAL215
D	ARG245
D	GLU299
D	HOH6876
D	HOH7068

site_id	JC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 6304

Chain	Residue
D	GLU117
D	ILE118
D	GLY207
D	VAL208
D	PHE243
D	ASP295
D	HOH6810
D	HOH7073

site_id	JC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL E 6205

Chain	Residue
E	PRO116
E	ASN209
E	LEU210
E	VAL215
E	ARG245
E	GLU299
E	HOH3598
E	HOH3601

site_id	JC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL E 6305

Chain	Residue
E	GLU117
E	ILE118
E	GLY207
E	VAL208
E	PHE243
E	ASP295
E	HOH3432

site_id	JC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL F 6206

Chain	Residue
F	PRO116
F	VAL208
F	ASN209
F	LEU210
F	VAL215
F	ARG245
F	GLU299
F	HOH6927

site_id	JC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL F 6306

Chain	Residue
F	GLU117
F	ILE118
F	GLY207
F	VAL208
F	PHE243
F	ASP295
F	GOL6057
F	HOH6523
F	HOH6679

site_id	JC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL G 6207

Chain	Residue
G	PRO116
G	VAL208
G	ASN209
G	LEU210
G	VAL215
G	ARG245
G	GLU299
G	HOH4188
G	HOH4189
G	GOL6307

site_id	JC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL G 6307

Chain	Residue
G	GLU117
G	ILE118
G	GLY207
G	VAL208
G	PHE243
G	ASP295
G	HOH2776
G	GOL6207

site_id	JC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL H 6208

Chain	Residue
H	PRO116
H	ASN209
H	LEU210
H	VAL215
H	ARG245
H	GLU299
H	HOH7028
H	HOH7059
H	HOH7103

site_id	JC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL H 6308

Chain	Residue
H	GLU117
H	ILE118
H	GLY207
H	VAL208
H	PHE243
H	ASP295
H	HOH6673

site_id	KC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL F 6001

Chain	Residue
F	LYS229
F	GLU233
F	ILE256
F	LEU257
F	LYS260
F	HOH6610
F	HOH6611

site_id	KC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 6002

Chain	Residue
A	ARG42
A	LYS65
A	SER66
A	GLY67
A	HIS378
A	HOH6844
A	HOH7129
A	HOH7141

site_id	KC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL G 6004

Chain	Residue
G	ALA37
G	PRO38
G	ILE39
G	THR40
G	ARG382
G	HOH3521
G	HOH3733

site_id	KC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL F 6005

Chain	Residue
F	ARG42
F	LYS65
F	SER66
F	GLY67
F	HIS378
F	HOH6638
F	HOH6642
F	HOH7067
F	HOH7071

site_id	KC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL H 6006

Chain	Residue
H	ILE64
H	PHE97
H	LEU103
H	ARG105
H	ARG499
H	HOH6896
H	HOH6963

site_id	KC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 6007

Chain	Residue
B	ARG42
B	LYS65
B	SER66
B	GLY67
B	HIS378
B	HOH6757
B	HOH6762

site_id	KC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL H 6008

Chain	Residue
H	ARG42
H	LYS65
H	SER66
H	GLY67
H	HIS378
H	HOH6551
H	HOH6895
H	HOH7069

site_id	KC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL F 6010

Chain	Residue
F	ASP177
F	GLN328
F	HOH6677
F	HOH7070
H	ARG338
H	PRO339
H	ARG341
H	HOH6777

site_id	KC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL E 6031

Chain	Residue
E	PRO52
E	HOH2717
E	HOH2718
E	HOH4678
E	HOH4816
E	EDO6045
H	PRO52
H	ARG55
H	TYR82
H	EDO6054
H	HOH6661

site_id	LC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL C 6055

Chain	Residue
C	ILE64
C	PHE97
C	LEU103
C	TYR104
C	ARG105
C	ARG499
C	HOH6538
C	HOH6540
C	HOH6778
C	HOH6946

site_id	LC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL C 6056

Chain	Residue
C	GLU417
C	TYR420
C	LYS421
C	HOH6582
C	HOH6584
C	HOH7019
C	HOH7054
D	ALA398
D	HOH7028

site_id	LC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL F 6057

Chain	Residue
F	ASP177
F	GLY294
F	ASP295
F	ILE298
F	PYR600
F	GOL6306
F	HOH6523

Functional Information from PROSITE/UniProt

site_id	PS00110
Number of Residues	13
Details	PYRUVATE_KINASE Pyruvate kinase active site signature. IkIISKIENhEGV

Chain	Residue	Details
A	ILE264-VAL276

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1792
Details	Region: {"description":"Interaction with POU5F1","evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	200
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P30613","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P00549","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	16
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	24
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	16
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P11980","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	16
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	16
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P52480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate","evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	16
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
A	LYS269
A	SER361
A	ARG119
A	GLU363
A	ARG72
A	THR327

site_id	CSA2
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
B	LYS269
B	SER361
B	ARG119
B	GLU363
B	ARG72
B	THR327

site_id	CSA3
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
C	LYS269
C	SER361
C	ARG119
C	GLU363
C	ARG72
C	THR327

site_id	CSA4
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
D	LYS269
D	SER361
D	ARG119
D	GLU363
D	ARG72
D	THR327

site_id	CSA5
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
E	LYS269
E	SER361
E	ARG119
E	GLU363
E	ARG72
E	THR327

site_id	CSA6
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
F	LYS269
F	SER361
F	ARG119
F	GLU363
F	ARG72
F	THR327

site_id	CSA7
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
G	LYS269
G	SER361
G	ARG119
G	GLU363
G	ARG72
G	THR327

site_id	CSA8
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
H	LYS269
H	SER361
H	ARG119
H	GLU363
H	ARG72
H	THR327

site_id	MCSA1
Number of Residues	4
Details	M-CSA 326

Chain	Residue	Details
A	ARG72	attractive charge-charge interaction, electrostatic stabiliser, steric role
A	ARG119	attractive charge-charge interaction, electrostatic stabiliser, steric role
A	LYS269	attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, steric role
A	THR327	electrostatic stabiliser, hydrogen bond donor, increase acidity

site_id	MCSA2
Number of Residues	4
Details	M-CSA 326

Chain	Residue	Details
B	ARG72	attractive charge-charge interaction, electrostatic stabiliser, steric role
B	ARG119	attractive charge-charge interaction, electrostatic stabiliser, steric role
B	LYS269	attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, steric role
B	THR327	electrostatic stabiliser, hydrogen bond donor, increase acidity

site_id	MCSA3
Number of Residues	4
Details	M-CSA 326

Chain	Residue	Details
C	ARG72	attractive charge-charge interaction, electrostatic stabiliser, steric role
C	ARG119	attractive charge-charge interaction, electrostatic stabiliser, steric role
C	LYS269	attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, steric role
C	THR327	electrostatic stabiliser, hydrogen bond donor, increase acidity

site_id	MCSA4
Number of Residues	4
Details	M-CSA 326

Chain	Residue	Details
D	ARG72	attractive charge-charge interaction, electrostatic stabiliser, steric role
D	ARG119	attractive charge-charge interaction, electrostatic stabiliser, steric role
D	LYS269	attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, steric role
D	THR327	electrostatic stabiliser, hydrogen bond donor, increase acidity

site_id	MCSA5
Number of Residues	4
Details	M-CSA 326

Chain	Residue	Details
E	ARG72	attractive charge-charge interaction, electrostatic stabiliser, steric role
E	ARG119	attractive charge-charge interaction, electrostatic stabiliser, steric role
E	LYS269	attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, steric role
E	THR327	electrostatic stabiliser, hydrogen bond donor, increase acidity

site_id	MCSA6
Number of Residues	4
Details	M-CSA 326

Chain	Residue	Details
F	ARG72	attractive charge-charge interaction, electrostatic stabiliser, steric role
F	ARG119	attractive charge-charge interaction, electrostatic stabiliser, steric role
F	LYS269	attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, steric role
F	THR327	electrostatic stabiliser, hydrogen bond donor, increase acidity

site_id	MCSA7
Number of Residues	4
Details	M-CSA 326

Chain	Residue	Details
G	ARG72	attractive charge-charge interaction, electrostatic stabiliser, steric role
G	ARG119	attractive charge-charge interaction, electrostatic stabiliser, steric role
G	LYS269	attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, steric role
G	THR327	electrostatic stabiliser, hydrogen bond donor, increase acidity

site_id	MCSA8
Number of Residues	4
Details	M-CSA 326

Chain	Residue	Details
H	ARG72	attractive charge-charge interaction, electrostatic stabiliser, steric role
H	ARG119	attractive charge-charge interaction, electrostatic stabiliser, steric role
H	LYS269	attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, steric role
H	THR327	electrostatic stabiliser, hydrogen bond donor, increase acidity

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)