2FTM
Crystal structure of trypsin complexed with the BPTI variant (Tyr35->Gly)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cationic trypsin | polymer | 223 | 23325.3 | 1 | UniProt (P00760) Pfam (PF00089) In PDB | Bos taurus | Beta-trypsin |
2 | B | Pancreatic trypsin inhibitor | polymer | 58 | 6421.4 | 1 | UniProt (P00974) Pfam (PF00014) In PDB | Bos taurus | Basic protease inhibitor, BPI, BPTI, Aprotinin |
3 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
4 | A, B | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
5 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
6 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
7 | water | water | 18.0 | 238 | Chemie (HOH) |
Sequence modifications
A: 16 - 238 (UniProt: P00760)
B: 1 - 58 (UniProt: P00974)
PDB | External Database | Details |
---|---|---|
Ias 115 | Asn 117 | engineered mutation |
Asp 115 | Asn 117 | microheterogeneity |
PDB | External Database | Details |
---|---|---|
Gly 35 | Tyr 70 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 29746.7 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 1216.0 | |
All* | Total formula weight | 30962.7 |