2FP4

Crystal structure of pig GTP-specific succinyl-CoA synthetase in complex with GTP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Succinyl-CoA ligase [GDP-forming] alpha-chain, mitochondrial	polymer	305	32168.8	1	UniProt (O19069-2) Pfam (PF02629) Pfam (PF00549) UniProt (by SIFTS) (O19069)	Sus scrofa (pig)	Succinyl-CoA synthetase, alpha chain, SCS-alpha
2	B (B)	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	polymer	395	42635.7	1	UniProt (P53590) Pfam (PF08442) Pfam (PF00549)	Sus scrofa (pig)	Succinyl-CoA synthetase, betaG chain, SCS-betaG, GTP- specific succinyl-CoA synthetase beta subunit, Fragment
3	C (B)	POTASSIUM ION	non-polymer		39.1	1	Chemie (K) PubChem (813)
4	D (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)
5	E, F (B)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466)
6	G, H (A, B)	water	water		18.0	294	Chemie (HOH)

Sequence modifications

A: 3 - 306 (UniProt: O19069-2)

PDB	External Database	Details
Ser 2	-	cloning artifact
Nep 259	His 285	modified residue

B: 2 - 395 (UniProt: P53590)

PDB	External Database	Details
Met 1	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74804.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1109.8
All*	Total formula weight	75914.3

*Water molecules are not included.