2FO4
Enhanced MHC class I binding and immune responses through anchor modification of the non-canonical tumor associated MUC1-8 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | H-2 class I histocompatibility antigen, K-B alpha chain | polymer | 274 | 31648.3 | 1 | UniProt (P01901) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (Q3UBW0) | Mus musculus (house mouse) | H-2KB |
| 2 | B (B) | Beta-2-microglobulin | polymer | 99 | 11704.4 | 1 | UniProt (P01887) Pfam (PF07654) | Mus musculus (house mouse) | |
| 3 | C (P) | 8-mer from Mucin-1 | polymer | 8 | 903.0 | 1 | UniProt (Q16615) UniProt (by SIFTS) (P15941) | MUCIN 1, TRANSMEMBRANE, MUC-1, Polymorphic epithelial mucin, PEM, PEMT, Episialin, Tumor-associated mucin, Carcinoma-associated mucin, Tumor-associated epithelial membrane antigen, EMA, H23AG, Peanut- reactive urinary mucin, PUM, Breast carcinoma-associated antigen DF3, CD227 antigen | |
| 4 | D (C) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 5 | E (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | F, G (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 7 | H, I, J, K (A, B) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 4 | Chemie (MPD) | |||
| 8 | L, M, N (A, B, P) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
P: 1 - 8 (UniProt: Q16615)
| PDB | External Database | Details |
|---|---|---|
| Phe 5 | Thr 924 | engineered mutation |
| Leu 8 | Ala 927 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 44255.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 367.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 883.8 | |
| All* | Total formula weight | 45506.9 |
