2FCI
Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Doubly phosphorylated peptide derived from Syk kinase comprising residues 338-350 | polymer | 14 | 1699.5 | 1 | UniProt (by SIFTS) (Q32PK0) In PDB | ||
| 2 | A | C-termainl SH2 domain from phospholipase C-gamma-1 comprising residues 663-759 | polymer | 105 | 12275.9 | 1 | UniProt (P08487) Pfam (PF00017) In PDB | Bos taurus (cattle) | PLC-gamma-1, Phospholipase C-gamma-1 |
Sequence modifications
A: 6 - 102 (UniProt: P08487)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | cloning artifact |
| Ser 2 | - | cloning artifact |
| Pro 3 | - | cloning artifact |
| Gly 4 | - | cloning artifact |
| Ile 5 | - | cloning artifact |
| Asn 103 | - | cloning artifact |
| Ser 104 | - | cloning artifact |
| Ser 105 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 13975.4 | |
| All* | Total formula weight | 13975.4 |
