2F9Q
Crystal Structure of Human Cytochrome P450 2D6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cytochrome P450 2D6 | polymer | 479 | 53808.6 | 4 | UniProt (P10635) Pfam (PF00067) | Homo sapiens (human) | CYPIID6; P450-DB1; Debrisoquine 4-hydroxylase |
| 2 | E, H, I, J (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, G (B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 23 - 497 (UniProt: P10635)
| PDB | External Database | Details |
|---|---|---|
| Ala 24 | His 24 | cloning artifact |
| Lys 25 | Arg 25 | cloning artifact |
| Lys 26 | Arg 26 | cloning artifact |
| Thr 27 | Gln 27 | cloning artifact |
| Ser 28 | Arg 28 | cloning artifact |
| Ser 29 | Trp 29 | cloning artifact |
| Lys 30 | Ala 30 | cloning artifact |
| Gly 31 | Ala 31 | cloning artifact |
| Lys 32 | Arg 32 | cloning artifact |
| Leu 33 | Tyr 33 | cloning artifact |
| Asp 230 | Leu 230 | engineered mutation |
| Arg 231 | Leu 231 | engineered mutation |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
| His 500 | - | expression tag |
| His 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 215234.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2658.1 | |
| All* | Total formula weight | 217892.5 |
