Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2F9Q

Crystal Structure of Human Cytochrome P450 2D6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008210	biological_process	estrogen metabolic process
A	0009804	biological_process	coumarin metabolic process
A	0009820	biological_process	alkaloid metabolic process
A	0009822	biological_process	alkaloid catabolic process
A	0016020	cellular_component	membrane
A	0016098	biological_process	monoterpenoid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0019369	biological_process	arachidonic acid metabolic process
A	0020037	molecular_function	heme binding
A	0033076	biological_process	isoquinoline alkaloid metabolic process
A	0042178	biological_process	xenobiotic catabolic process
A	0042572	biological_process	retinol metabolic process
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046483	biological_process	obsolete heterocycle metabolic process
A	0046872	molecular_function	metal ion binding
A	0051100	biological_process	negative regulation of binding
A	0062187	molecular_function	anandamide 8,9 epoxidase activity
A	0062188	molecular_function	anandamide 11,12 epoxidase activity
A	0062189	molecular_function	anandamide 14,15 epoxidase activity
A	0070989	biological_process	oxidative demethylation
A	0090350	biological_process	negative regulation of cellular organofluorine metabolic process
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008210	biological_process	estrogen metabolic process
B	0009804	biological_process	coumarin metabolic process
B	0009820	biological_process	alkaloid metabolic process
B	0009822	biological_process	alkaloid catabolic process
B	0016020	cellular_component	membrane
B	0016098	biological_process	monoterpenoid metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
B	0019369	biological_process	arachidonic acid metabolic process
B	0020037	molecular_function	heme binding
B	0033076	biological_process	isoquinoline alkaloid metabolic process
B	0042178	biological_process	xenobiotic catabolic process
B	0042572	biological_process	retinol metabolic process
B	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046483	biological_process	obsolete heterocycle metabolic process
B	0046872	molecular_function	metal ion binding
B	0051100	biological_process	negative regulation of binding
B	0062187	molecular_function	anandamide 8,9 epoxidase activity
B	0062188	molecular_function	anandamide 11,12 epoxidase activity
B	0062189	molecular_function	anandamide 14,15 epoxidase activity
B	0070989	biological_process	oxidative demethylation
B	0090350	biological_process	negative regulation of cellular organofluorine metabolic process
C	0004497	molecular_function	monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006805	biological_process	xenobiotic metabolic process
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0008210	biological_process	estrogen metabolic process
C	0009804	biological_process	coumarin metabolic process
C	0009820	biological_process	alkaloid metabolic process
C	0009822	biological_process	alkaloid catabolic process
C	0016020	cellular_component	membrane
C	0016098	biological_process	monoterpenoid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
C	0019369	biological_process	arachidonic acid metabolic process
C	0020037	molecular_function	heme binding
C	0033076	biological_process	isoquinoline alkaloid metabolic process
C	0042178	biological_process	xenobiotic catabolic process
C	0042572	biological_process	retinol metabolic process
C	0042759	biological_process	long-chain fatty acid biosynthetic process
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0046483	biological_process	obsolete heterocycle metabolic process
C	0046872	molecular_function	metal ion binding
C	0051100	biological_process	negative regulation of binding
C	0062187	molecular_function	anandamide 8,9 epoxidase activity
C	0062188	molecular_function	anandamide 11,12 epoxidase activity
C	0062189	molecular_function	anandamide 14,15 epoxidase activity
C	0070989	biological_process	oxidative demethylation
C	0090350	biological_process	negative regulation of cellular organofluorine metabolic process
D	0004497	molecular_function	monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006805	biological_process	xenobiotic metabolic process
D	0008202	biological_process	steroid metabolic process
D	0008203	biological_process	cholesterol metabolic process
D	0008210	biological_process	estrogen metabolic process
D	0009804	biological_process	coumarin metabolic process
D	0009820	biological_process	alkaloid metabolic process
D	0009822	biological_process	alkaloid catabolic process
D	0016020	cellular_component	membrane
D	0016098	biological_process	monoterpenoid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
D	0019369	biological_process	arachidonic acid metabolic process
D	0020037	molecular_function	heme binding
D	0033076	biological_process	isoquinoline alkaloid metabolic process
D	0042178	biological_process	xenobiotic catabolic process
D	0042572	biological_process	retinol metabolic process
D	0042759	biological_process	long-chain fatty acid biosynthetic process
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0046483	biological_process	obsolete heterocycle metabolic process
D	0046872	molecular_function	metal ion binding
D	0051100	biological_process	negative regulation of binding
D	0062187	molecular_function	anandamide 8,9 epoxidase activity
D	0062188	molecular_function	anandamide 11,12 epoxidase activity
D	0062189	molecular_function	anandamide 14,15 epoxidase activity
D	0070989	biological_process	oxidative demethylation
D	0090350	biological_process	negative regulation of cellular organofluorine metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 2000

Chain	Residue
B	ARG129
B	ARG133
D	ARG129
D	ARG133

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 2001

Chain	Residue
D	ARG440
B	ARG129
B	ARG133
B	ARG440
D	ARG129
D	ARG133

site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM A 600

Chain	Residue
A	ARG101
A	VAL119
A	PHE120
A	TRP128
A	ARG132
A	ALA305
A	GLY306
A	THR309
A	THR310
A	THR313
A	GLN364
A	HIS376
A	PRO435
A	PHE436
A	SER437
A	ARG441
A	CYS443
A	LEU444
A	GLY445
A	GLU452

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM B 600

Chain	Residue
B	ARG101
B	VAL119
B	PHE120
B	TRP128
B	ARG132
B	ALA305
B	GLY306
B	THR309
B	THR310
B	HIS376
B	PRO435
B	PHE436
B	SER437
B	ARG441
B	CYS443
B	LEU444
B	GLY445

site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM C 600

Chain	Residue
C	ARG101
C	VAL119
C	PHE120
C	TRP128
C	ARG132
C	ALA305
C	GLY306
C	THR309
C	THR310
C	THR313
C	HIS376
C	PRO435
C	PHE436
C	SER437
C	ARG441
C	CYS443
C	LEU444
C	GLY445
C	GLU452

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM D 600

Chain	Residue
D	ARG101
D	VAL119
D	PHE120
D	TRP128
D	ARG132
D	LEU302
D	ALA305
D	GLY306
D	THR309
D	THR310
D	THR313
D	HIS376
D	PRO435
D	PHE436
D	SER437
D	ARG441
D	CYS443
D	LEU444
D	GLY445
D	GLU452

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSaGRRACLG

Chain	Residue	Details
A	PHE436-GLY445

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	ASP301
B	ASP301
C	ASP301
D	ASP301

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: axial binding residue

Chain	Residue	Details
A	CYS443
B	CYS443
C	CYS443
D	CYS443

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)