2F57

Crystal Structure Of The Human P21-Activated Kinase 5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Serine/threonine-protein kinase PAK 7	polymer	317	36248.7	2	UniProt (Q9P286) Pfam (PF00069) In PDB	Homo sapiens (human)	p21-activated kinase 7, PAK-7, PAK-5
2	A	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		122.1	2	Chemie (TRS)
3	B	N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE	non-polymer		385.9	1	Chemie (23D)
4		water	water		18.0	613	Chemie (HOH)

Sequence modifications

A, B: 425 - 719 (UniProt: Q9P286)

PDB	External Database	Details
Met -21	-	cloning artifact
Gly -20	-	cloning artifact
Ser -19	-	cloning artifact
Ser -18	-	cloning artifact
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Ser -11	-	cloning artifact
Ser -10	-	cloning artifact
Gly -9	-	cloning artifact
Arg -8	-	cloning artifact
Glu -7	-	cloning artifact
Asn -6	-	cloning artifact
Leu -5	-	cloning artifact
Tyr -4	-	cloning artifact
Phe -3	-	cloning artifact
Gln -2	-	cloning artifact
Ser -1	-	cloning artifact
Met 0	-	cloning artifact
Sep 602	Ser 602	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72497.5
Non-Polymers*	Number of molecules	3
	Total formula weight	630.2
All*	Total formula weight	73127.6

*Water molecules are not included.