2F4J
Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Proto-oncogene tyrosine-protein kinase ABL1 | polymer | 287 | 33171.9 | 1 | GenBank (62362414) Pfam (PF07714) UniProt (by SIFTS) (P00519) In PDB | Homo sapiens (human) | p150, c- ABL |
| 2 | A | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE | non-polymer | 464.6 | 1 | Chemie (VX6) | |||
| 3 | water | water | 18.0 | 211 | Chemie (HOH) |
Sequence modifications
A: 227 - 513 (GenBank: 62362414)
| PDB | External Database | Details |
|---|---|---|
| Pro 396 | His 396 | engineered mutation |
| Met 228 | Val 228 | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33171.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 464.6 | |
| All* | Total formula weight | 33636.5 |
