2F2T

Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.7 A resolution with 5-Aminoisoquinoline bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Nucleoside 2-deoxyribosyltransferase	polymer	161	18664.1	2	UniProt (Q57VC7) Pfam (PF05014)	Trypanosoma brucei
2	C, F (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	D, G (A, B)	ISOQUINOLIN-5-AMINE	non-polymer		144.2	2	Chemie (5IQ)
4	E, H (A, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	I, J (A, B)	water	water		18.0	393	Chemie (HOH)

Sequence modifications

A, B: 9 - 161 (UniProt: Q57VC7)

PDB	External Database	Details
Mse 1	-	cloning artifact
Ala 2	-	cloning artifact
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
Mse 9	Met 1	modified residue
Mse 24	Met 16	modified residue
Mse 42	Met 34	modified residue
Glu 53	Gly 45	see remark 999
Mse 64	Met 56	modified residue
Cys 93	Tyr 85	see remark 999
Mse 100	Met 92	modified residue
Mse 111	Met 103	modified residue
Gly 118	Glu 110	see remark 999
Mse 136	Met 128	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	37328.1
Non-Polymers*	Number of molecules	6
	Total formula weight	664.7
All*	Total formula weight	37992.8

*Water molecules are not included.