2ESA
GRP94 n-terminal domain bound to geldanamycin: effects of mutants 168-169 KS-AA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Endoplasmin | polymer | 236 | 26439.9 | 1 | UniProt (P41148) Pfam (PF13589) | Canis lupus familiaris (dog) | 94 kDa glucose-regulated protein, GRP94 |
| 2 | B (A) | GELDANAMYCIN | non-polymer | 560.6 | 1 | Chemie (GDM) | |||
| 3 | C (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 4 | D, E (A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 5 | F (A) | water | water | 18.0 | 332 | Chemie (HOH) |
Sequence modifications
A: 69 - 286 (UniProt: P41148)
A: 328 - 337 (UniProt: P41148)
| PDB | External Database | Details |
|---|---|---|
| Gly 65 | - | cloning artifact |
| Ser 66 | - | cloning artifact |
| His 67 | - | cloning artifact |
| Met 68 | - | cloning artifact |
| Ala 168 | Lys 168 | engineered mutation |
| Ala 169 | Ser 169 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 287 | - | SEE REMARK 999 |
| Gly 288 | - | SEE REMARK 999 |
| Gly 289 | - | SEE REMARK 999 |
| Gly 290 | - | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26439.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1055.2 | |
| All* | Total formula weight | 27495.1 |
