2E7A

TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Tumor necrosis factor	polymer	157	17299.3	3	UniProt (P01375) Pfam (PF00229) In PDB	Homo sapiens (human)	TNF
2		water	water		18.0	237	Chemie (HOH)

Sequence modifications

A, B, C: 1 - 157 (UniProt: P01375)

PDB	External Database	Details
Met 11	Lys 87	engineered mutation
Ser 65	Lys 141	engineered mutation
Ser 84	Ala 160	engineered mutation
Thr 85	Val 161	engineered mutation
Thr 86	Ser 162	engineered mutation
His 87	Tyr 163	engineered mutation
Asn 88	Gln 164	engineered mutation
Gln 89	Thr 165	engineered mutation
Pro 90	Lys 166	engineered mutation
Arg 98	Lys 174	engineered mutation
Asn 112	Lys 188	engineered mutation
Pro 128	Lys 204	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	51898.0
All*	Total formula weight	51898.0

*Water molecules are not included.