2DO2
Design of specific inhibitors of phospholipase A2: Crystal structure of the complex formed between a group II Cys 49 phospholipase A2 and a designed pentapeptide Ala-Leu-Ala-Ser-Lys at 2.6A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phospholipase A2 VRV-PL-VIIIa | polymer | 121 | 13492.7 | 1 | UniProt (P59071) Pfam (PF00068) In PDB | Daboia russellii pulchella | Phosphatidylcholine 2-acylhydrolase, DPLA2 |
| 2 | P | Ala-Leu-Ala-Ser-Lys | polymer | 5 | 489.6 | 1 | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A: 1 - 133 (UniProt: P59071)
| PDB | External Database | Details |
|---|---|---|
| Gly 30 | Trp 30 | SEE REMARK 999 |
| Cys 32 | Gly 31 | SEE REMARK 999 |
| Ser 34 | Lys 33 | SEE REMARK 999 |
| Cys 49 | Asp 48 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 13982.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 96.1 | |
| All* | Total formula weight | 14078.3 |
