2DG9
FK506-binding protein mutant WL59 complexed with Rapamycin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | FK506-binding protein 1A | polymer | 107 | 11763.5 | 1 | UniProt (P62942) Pfam (PF00254) | Homo sapiens (human) | Peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase, 12 kDa FKBP, FKBP-12, Immunophilin FKBP12 |
| 2 | B (A) | RAPAMYCIN IMMUNOSUPPRESSANT DRUG | non-polymer | 914.2 | 1 | Chemie (RAP) PubChem (21944094) PubChem (22524702) PubChem (22524747) PubChem (22525359) PubChem (176856347) PubChem (23351774) PubChem (23375411) PubChem (23376986) PubChem (23748515) PubChem (24870962) PubChem (24871327) PubChem (25200053) PubChem (25200063) PubChem (44120108) PubChem (16760052) PubChem (16760631) PubChem (17753749) PubChem (44476572) PubChem (44634693) PubChem (21176130) PubChem (21549991) PubChem (21863017) PubChem (22524575) PubChem (22525016) PubChem (22771180) PubChem (22829016) PubChem (23351773) PubChem (23375412) PubChem (23376988) PubChem (24150662) PubChem (24867259) PubChem (24871317) PubChem (25200284) PubChem (25200075) PubChem (25200308) PubChem (25266201) PubChem (54600319) PubChem (57579211) PubChem (57831856) PubChem (44295234) PubChem (58597069) PubChem (58597081) PubChem (58651220) PubChem (58651224) PubChem (58682959) PubChem (58725682) PubChem (58725688) PubChem (58731856) PubChem (58757256) PubChem (58818830) PubChem (58942911) PubChem (59079213) PubChem (59116632) PubChem (59262957) PubChem (44634703) PubChem (59716030) PubChem (59746150) PubChem (59761584) PubChem (59798735) PubChem (46835353) PubChem (59976377) PubChem (49652385) PubChem (70789198) PubChem (71296106) PubChem (53298413) PubChem (53627520) PubChem (478951) PubChem (73265225) PubChem (73438908) PubChem (145684635) PubChem (57312764) PubChem (57549339) PubChem (57747481) PubChem (57654444) PubChem (73896879) PubChem (57542109) PubChem (57831854) PubChem (58651218) PubChem (58731853) PubChem (58863407) PubChem (58681233) PubChem (58651217) PubChem (58682966) PubChem (58725690) PubChem (59032409) PubChem (59111212) PubChem (59079212) PubChem (59189008) PubChem (59584560) PubChem (59873116) PubChem (59741796) PubChem (59514927) PubChem (59695672) PubChem (59762850) PubChem (59716029) PubChem (59746146) PubChem (59798734) PubChem (59836921) PubChem (59762848) PubChem (59939263) PubChem (59843436) PubChem (60084327) PubChem (59965662) PubChem (59921726) PubChem (59972802) PubChem (59982608) PubChem (60003176) PubChem (60148419) PubChem (60146796) PubChem (86583604) PubChem (60150249) PubChem (88543353) PubChem (88877093) PubChem (88877541) PubChem (88982079) PubChem (143131348) PubChem (176481738) PubChem (89172501) PubChem (89222646) PubChem (89229297) PubChem (89288626) PubChem (176797660) PubChem (176878509) PubChem (177257072) PubChem (177410779) PubChem (5040) PubChem (65448) PubChem (90660428) PubChem (90660646) PubChem (313006) PubChem (71308609) PubChem (71463321) PubChem (73438890) PubChem (73707374) PubChem (73952167) PubChem (87199396) PubChem (87413824) PubChem (88877157) PubChem (88876970) PubChem (88938482) PubChem (88934904) PubChem (89164572) PubChem (89173639) PubChem (89263866) PubChem (89193790) PubChem (89203820) PubChem (89203981) PubChem (89382243) PubChem (89651883) PubChem (89691897) PubChem (91157894) PubChem (90830213) PubChem (90954095) PubChem (91059082) PubChem (91312280) PubChem (91407558) PubChem (5358081) PubChem (5284616) PubChem (98042555) PubChem (99726904) PubChem (99726905) PubChem (99719687) PubChem (99726902) PubChem (99719685) PubChem (101058122) PubChem (5374464) PubChem (5460439) PubChem (5497196) PubChem (5924240) PubChem (118028380) PubChem (6610346) PubChem (6711160) PubChem (6713081) PubChem (123319649) PubChem (123375319) PubChem (123284252) PubChem (123579029) PubChem (123745020) PubChem (123961550) PubChem (124202144) PubChem (124202163) PubChem (9833581) PubChem (9854379) PubChem (124923869) PubChem (125182984) PubChem (9962926) PubChem (126706235) PubChem (6436030) PubChem (129018336) PubChem (10213190) PubChem (129396805) PubChem (131674889) PubChem (131668123) PubChem (132342626) PubChem (6610270) PubChem (133550001) PubChem (99719686) PubChem (99726903) PubChem (118701644) PubChem (118968446) PubChem (134812764) PubChem (11959112) PubChem (9854380) PubChem (136197703) PubChem (137146980) PubChem (137126527) PubChem (9962928) PubChem (137154395) PubChem (137154392) PubChem (137154394) PubChem (137159082) PubChem (137303712) PubChem (137321130) PubChem (123132513) PubChem (123685353) PubChem (137513797) PubChem (123966602) PubChem (124202326) PubChem (140457701) PubChem (140509544) PubChem (140495012) PubChem (141827210) PubChem (11949238) PubChem (13003162) PubChem (146165671) PubChem (149030593) PubChem (149030595) PubChem (154539809) PubChem (155923785) PubChem (154575194) PubChem (124923870) PubChem (124923871) PubChem (124923872) PubChem (157691735) PubChem (158004723) PubChem (158004725) PubChem (158667905) PubChem (158667900) PubChem (159512395) PubChem (160401076) PubChem (160401082) PubChem (160401068) PubChem (160843420) PubChem (160401063) PubChem (160401067) PubChem (160401073) PubChem (160843418) PubChem (160401077) PubChem (160559912) PubChem (161552714) PubChem (162393098) PubChem (162702738) PubChem (162907223) PubChem (162907225) PubChem (162907221) PubChem (163193694) PubChem (163359781) PubChem (163895655) PubChem (163895656) PubChem (163978502) PubChem (166639084) PubChem (167403487) PubChem (168267583) PubChem (168314647) PubChem (168843998) PubChem (168810792) PubChem (169766759) PubChem (170922362) PubChem (170996834) PubChem (171042528) PubChem (171329380) PubChem (171360948) PubChem (171607084) PubChem (171991699) PubChem (129010340) PubChem (173549023) PubChem (173303291) PubChem (173381240) PubChem (173209376) PubChem (173484164) PubChem (173477043) PubChem (173523625) PubChem (173644621) PubChem (173628231) PubChem (173732063) PubChem (173790728) PubChem (174051096) PubChem (174079707) PubChem (174086051) PubChem (175963732) PubChem (129150908) PubChem (134129699) PubChem (134572840) PubChem (134760597) PubChem (137146981) PubChem (137146982) PubChem (137154393) PubChem (137244727) PubChem (137795242) PubChem (138106895) PubChem (138404388) PubChem (140456940) PubChem (140495013) PubChem (140504269) PubChem (149030591) PubChem (149030592) PubChem (149030594) PubChem (153274811) PubChem (153484733) PubChem (154547638) PubChem (157502692) PubChem (157507229) PubChem (160401064) PubChem (160401065) PubChem (160401066) PubChem (160401069) PubChem (160401070) PubChem (160401071) PubChem (160401072) PubChem (160401074) PubChem (160401075) PubChem (160401078) PubChem (160401079) PubChem (160401080) PubChem (160401081) PubChem (161095401) PubChem (161095402) PubChem (161418798) PubChem (162907222) PubChem (162907224) PubChem (163895657) PubChem (166604446) PubChem (168311769) PubChem (169962415) PubChem (171125838) PubChem (171159772) PubChem (171703108) PubChem (171761843) PubChem (172017404) PubChem (172018138) PubChem (172503251) PubChem (173075346) PubChem (173296700) PubChem (173303290) PubChem (173303292) PubChem (173303664) PubChem (173382757) PubChem (173481203) PubChem (173493552) PubChem (173512554) PubChem (173614191) PubChem (173682385) PubChem (175673538) PubChem (175737102) PubChem (176418841) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 4 | D (A) | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence modifications
A: 1 - 107 (UniProt: P62942)
| PDB | External Database | Details |
|---|---|---|
| Leu 59 | Trp 60 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11763.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1006.3 | |
| All* | Total formula weight | 12769.7 |
