2D9Q
Crystal Structure of the Human GCSF-Receptor Signaling Complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | CSF3 | polymer | 174 | 18685.6 | 1 | UniProt (P09919) Pfam (PF16647) In PDB | Homo sapiens (human) | Granulocyte colony stimulating factor, GCSF |
2 | B | Granulocyte colony-stimulating factor receptor | polymer | 313 | 34709.7 | 1 | UniProt (Q99062) Pfam (PF06328) In PDB | Homo sapiens (human) | G-CSF-R, CD114 antigen, GCSF-R |
3 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
4 | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
B: 2 - 309 (UniProt: Q99062)
PDB | External Database | Details |
---|---|---|
Ser 79 | Cys 102 | engineered mutation |
Ser 164 | Cys 187 | engineered mutation |
Ser 229 | Cys 252 | engineered mutation |
Ala 310 | - | cloning artifact |
Ala 311 | - | cloning artifact |
Ala 312 | - | cloning artifact |
Pro 313 | - | cloning artifact |
Arg 314 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 53395.3 | |
Branched | Number of molecules | 1 |
Total formula weight | 424.4 | |
All* | Total formula weight | 53819.7 |