2D9Q
Crystal Structure of the Human GCSF-Receptor Signaling Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CSF3 | polymer | 174 | 18685.6 | 1 | UniProt (P09919) Pfam (PF16647) | Homo sapiens (human) | Granulocyte colony stimulating factor, GCSF |
| 2 | B (B) | Granulocyte colony-stimulating factor receptor | polymer | 313 | 34709.7 | 1 | UniProt (Q99062) Pfam (PF06328) | Homo sapiens (human) | G-CSF-R, CD114 antigen, GCSF-R |
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
B: 2 - 309 (UniProt: Q99062)
| PDB | External Database | Details |
|---|---|---|
| Ser 79 | Cys 102 | engineered mutation |
| Ser 164 | Cys 187 | engineered mutation |
| Ser 229 | Cys 252 | engineered mutation |
| Ala 310 | - | cloning artifact |
| Ala 311 | - | cloning artifact |
| Ala 312 | - | cloning artifact |
| Pro 313 | - | cloning artifact |
| Arg 314 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53395.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| All* | Total formula weight | 53819.7 |
