2D9Q
Crystal Structure of the Human GCSF-Receptor Signaling Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005130 | molecular_function | granulocyte colony-stimulating factor receptor binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006955 | biological_process | immune response |
| A | 0008083 | molecular_function | growth factor activity |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0019221 | biological_process | cytokine-mediated signaling pathway |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0030225 | biological_process | macrophage differentiation |
| A | 0030838 | biological_process | positive regulation of actin filament polymerization |
| A | 0030851 | biological_process | granulocyte differentiation |
| A | 0038158 | biological_process | granulocyte colony-stimulating factor signaling pathway |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0045471 | biological_process | response to ethanol |
| A | 0045639 | biological_process | positive regulation of myeloid cell differentiation |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0051897 | biological_process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| A | 0071222 | biological_process | cellular response to lipopolysaccharide |
| A | 0071345 | biological_process | cellular response to cytokine stimulus |
| A | 0071682 | cellular_component | endocytic vesicle lumen |
| A | 0110053 | biological_process | regulation of actin filament organization |
Functional Information from PROSITE/UniProt
| site_id | PS00254 |
| Number of Residues | 26 |
| Details | INTERLEUKIN_6 Interleukin-6 / G-CSF / MGF signature. CpsqalqlagClsqlhsGLflYqglL |
| Chain | Residue | Details |
| A | CYS64-LEU89 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 105 |
| Details | Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Motif: {"description":"WSXWS motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16492764","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
