2D9Q

Crystal Structure of the Human GCSF-Receptor Signaling Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005102	molecular_function	signaling receptor binding
A	0005125	molecular_function	cytokine activity
A	0005130	molecular_function	granulocyte colony-stimulating factor receptor binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006955	biological_process	immune response
A	0008083	molecular_function	growth factor activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0019899	molecular_function	enzyme binding
A	0030838	biological_process	positive regulation of actin filament polymerization
A	0030851	biological_process	granulocyte differentiation
A	0038158	biological_process	granulocyte colony-stimulating factor signaling pathway
A	0043202	cellular_component	lysosomal lumen
A	0045471	biological_process	response to ethanol
A	0045639	biological_process	positive regulation of myeloid cell differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071345	biological_process	cellular response to cytokine stimulus
A	0071682	cellular_component	endocytic vesicle lumen
A	0110053	biological_process	regulation of actin filament organization

Functional Information from PROSITE/UniProt

site_id	PS00254
Number of Residues	26
Details	INTERLEUKIN_6 Interleukin-6 / G-CSF / MGF signature. CpsqalqlagClsqlhsGLflYqglL

Chain	Residue	Details
A	CYS64-LEU89

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	105
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16492764","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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