2D5V

Crystal structure of HNF-6alpha DNA-binding domain in complex with the TTR promoter

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (C, E)	5'-D(*TP*CP*TP*AP*AP*GP*TP*CP*AP*AP*TP*AP*AP*T)-3'	polymer	14	4262.8	2
2	B, D (D, F)	5'-D(*AP*TP*TP*AP*TP*TP*GP*AP*CP*TP*TP*AP*GP*A)-3'	polymer	14	4293.8	2
3	E, F (A, B)	Hepatocyte nuclear factor 6	polymer	164	19663.8	2	UniProt (P70512) Pfam (PF02376) Pfam (PF00046)	Rattus norvegicus (Norway rat)	HNF-6, One cut domain family member 1
4	G, H (D, E)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
5	I, J (B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	K, L, M, N, O... (C, D, E, F, A...)	water	water		18.0	195	Chemie (HOH)

Sequence modifications

A, B: 1 - 156 (UniProt: P70512)

PDB	External Database	Details
Leu 157	-	expression tag
Glu 158	-	expression tag
His 159	-	expression tag
His 160	-	expression tag
His 161	-	expression tag
His 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	56440.8
Non-Polymers*	Number of molecules	4
	Total formula weight	302.3
All*	Total formula weight	56743.1

*Water molecules are not included.