2CF8

Complex of recombinant human thrombin with an inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	THROMBIN HEAVY CHAIN	polymer	257	29594.1	1	UniProt (P00734) Pfam (PF00089) In PDB	HOMO SAPIENS (HUMAN)
2	I	HIRUDIN IIIA	polymer	11	1396.5	1	UniProt (P28508) In PDB BIRD (PRD_000481)	HIRUDO MEDICINALIS
3	L	THROMBIN LIGHT CHAIN	polymer	28	3303.7	1	UniProt (P00734) Pfam (PF09396) In PDB	HOMO SAPIENS (HUMAN)
4	H	4- [(1R,3AS,4R,8AS,8BR)- 2- (4-CHLOROBENZYL)- 1- ISOPROPYL- 3- OXODECAHYDROPYRROLO[3,4- A]PYRROLIZIN- 4- YL]BENZENECARBOXIMIDAMIDE	non-polymer		451.0	1	Chemie (ESH)
5	H	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6	H	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
7		water	water		18.0	397	Chemie (HOH)

Sequence modifications

I: 1 - 1 (PDB: 2CF8)
I: 2 - 11 (UniProt: P28508)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	34294.2
Non-Polymers*	Number of molecules	3
	Total formula weight	514.1
All*	Total formula weight	34808.3

*Water molecules are not included.