2C0T
Src family kinase Hck with bound inhibitor A-641359
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | TYROSINE-PROTEIN KINASE HCK | polymer | 454 | 52000.2 | 2 | UniProt (P08631) Pfam (PF00018) Pfam (PF00017) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | HAEMATOPOETIC CELL KINASE HCK, P59-HCK/P60-HCK HEMOPOIETIC CELL KINASE |
2 | A, B | N-(4-{4-AMINO-1-[1-(TETRAHYDRO-2H-PYRAN-4-YL)PIPERIDIN-4-YL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE | non-polymer | 580.7 | 2 | Chemie (L3G) | |||
3 | A, B | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
4 | water | water | 18.0 | 200 | Chemie (HOH) |
Sequence modifications
A, B: 52 - 59 (PDB: 2C0T)
A, B: 60 - 505 (UniProt: P08631)
A, B: 60 - 505 (UniProt: P08631)
PDB | External Database | Details |
---|---|---|
Glu 502 | Gln 522 | engineered mutation |
Glu 503 | Gln 523 | engineered mutation |
Ile 504 | Gln 524 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 104000.5 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1321.7 | |
All* | Total formula weight | 105322.1 |