2BXU
Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | ALPHA THROMBIN | polymer | 259 | 29780.2 | 1 | UniProt (P00734) Pfam (PF00089) | HOMO SAPIENS (HUMAN) | COAGULATION FACTOR II |
| 2 | B (I) | HIRUDIN | polymer | 11 | 1420.5 | 1 | UniProt (P09945) | HIRUDO MEDICINALIS | |
| 3 | C (L) | ALPHA THROMBIN | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | HOMO SAPIENS (HUMAN) | COAGULATION FACTOR II |
| 4 | D (H) | 1-(2-{[(6-AMINO-2-METHYLPYRIDIN-3-YL)METHYL]AMINO}ETHYL)-6-CHLORO-3-[(2,2-DIFLUORO-2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL | non-polymer | 457.9 | 1 | Chemie (C1D) | |||
| 5 | E, F, G (H, I, L) | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 35297.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 457.9 | |
| All* | Total formula weight | 35755.2 |
